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Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry

INTRODUCTION: The purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory concerns and...

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Autores principales: Mackin, R. Scott, Insel, Philip S., Truran, Diana, Finley, Shannon, Flenniken, Derek, Nosheny, Rachel, Ulbright, Aaron, Comacho, Monica, Bickford, David, Harel, Brian, Maruff, Paul, Weiner, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215059/
https://www.ncbi.nlm.nih.gov/pubmed/30406176
http://dx.doi.org/10.1016/j.dadm.2018.05.005
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author Mackin, R. Scott
Insel, Philip S.
Truran, Diana
Finley, Shannon
Flenniken, Derek
Nosheny, Rachel
Ulbright, Aaron
Comacho, Monica
Bickford, David
Harel, Brian
Maruff, Paul
Weiner, Michael W.
author_facet Mackin, R. Scott
Insel, Philip S.
Truran, Diana
Finley, Shannon
Flenniken, Derek
Nosheny, Rachel
Ulbright, Aaron
Comacho, Monica
Bickford, David
Harel, Brian
Maruff, Paul
Weiner, Michael W.
author_sort Mackin, R. Scott
collection PubMed
description INTRODUCTION: The purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory concerns and family history of dementia on cognitive performance. METHODS: Participants completed the Cogstate Brief Battery unsupervised at home. RESULTS: Data from 6463 participants over the age of 55 years were analyzed. Adults with the diagnosis of mild cognitive impairment and Alzheimer's disease were associated with poorer performance on all cognitive tests than cognitively normal adults (P < .05 for all), and online cognitive test performance significantly improved diagnostic classification (P < .001). Poorer performance on all cognitive measures was associated with memory concern (P < .001 for all) but not family history of dementia. DISCUSSION: Our results provide preliminary support for the use of cognitive tests taken online without supervision as a means to improve the efficiency of participant screening and recruitment for clinical trials.
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spelling pubmed-62150592018-11-07 Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry Mackin, R. Scott Insel, Philip S. Truran, Diana Finley, Shannon Flenniken, Derek Nosheny, Rachel Ulbright, Aaron Comacho, Monica Bickford, David Harel, Brian Maruff, Paul Weiner, Michael W. Alzheimers Dement (Amst) Cognitive & Behavioral Assessment INTRODUCTION: The purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory concerns and family history of dementia on cognitive performance. METHODS: Participants completed the Cogstate Brief Battery unsupervised at home. RESULTS: Data from 6463 participants over the age of 55 years were analyzed. Adults with the diagnosis of mild cognitive impairment and Alzheimer's disease were associated with poorer performance on all cognitive tests than cognitively normal adults (P < .05 for all), and online cognitive test performance significantly improved diagnostic classification (P < .001). Poorer performance on all cognitive measures was associated with memory concern (P < .001 for all) but not family history of dementia. DISCUSSION: Our results provide preliminary support for the use of cognitive tests taken online without supervision as a means to improve the efficiency of participant screening and recruitment for clinical trials. Elsevier 2018-06-21 /pmc/articles/PMC6215059/ /pubmed/30406176 http://dx.doi.org/10.1016/j.dadm.2018.05.005 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Cognitive & Behavioral Assessment
Mackin, R. Scott
Insel, Philip S.
Truran, Diana
Finley, Shannon
Flenniken, Derek
Nosheny, Rachel
Ulbright, Aaron
Comacho, Monica
Bickford, David
Harel, Brian
Maruff, Paul
Weiner, Michael W.
Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_full Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_fullStr Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_full_unstemmed Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_short Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_sort unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: results from the brain health registry
topic Cognitive & Behavioral Assessment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215059/
https://www.ncbi.nlm.nih.gov/pubmed/30406176
http://dx.doi.org/10.1016/j.dadm.2018.05.005
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