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A Plasmonic Fiber Based Glucometer and Its Temperature Dependence

We present the plasmonic fiber based optical glucometer. A thin gold layer is coated on clad-free core of multimode optical fiber along 3 cm length to excite surface plasmons at 632.8 nm wavelength. Glucose oxidase is immobilized on the metal surface for glucose sensing. The effective surface refrac...

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Autores principales: Kim, Jisoo, Son, Changjin, Choi, Sunjak, Yoon, Won Jung, Ju, Heongkyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215121/
https://www.ncbi.nlm.nih.gov/pubmed/30424439
http://dx.doi.org/10.3390/mi9100506
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author Kim, Jisoo
Son, Changjin
Choi, Sunjak
Yoon, Won Jung
Ju, Heongkyu
author_facet Kim, Jisoo
Son, Changjin
Choi, Sunjak
Yoon, Won Jung
Ju, Heongkyu
author_sort Kim, Jisoo
collection PubMed
description We present the plasmonic fiber based optical glucometer. A thin gold layer is coated on clad-free core of multimode optical fiber along 3 cm length to excite surface plasmons at 632.8 nm wavelength. Glucose oxidase is immobilized on the metal surface for glucose sensing. The effective surface refractive index increases by gluconic acid and hydrogen peroxide that are generated upon glucose injection, leading to plasmonic condition change with a consequence of optical power change at the fiber output. We obtain limit of detection of glucose concentration of 6.75 mg/dL, indicating higher sensitivity than the wavelength interrogating SPR glucometer that uses a spectrometer of 1nm spectral resolution. The coefficient of variation is 8.6% at a glucose concentration of 80 mg/dL at room temperature. We also examine the effects of ambient temperature variations from −10 °C to 40 °C on the performance of the presented sensor and compared them with those on commercially available glucometers that are based on enzyme electrodes. We find that the presented fiber sensor produced standard deviation of 12.1 mg/dL at a glucose concentration of 80 mg/dL under such varying temperature, which is, even without additional temperature correction function, comparable to the commercialized ones.
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spelling pubmed-62151212018-11-06 A Plasmonic Fiber Based Glucometer and Its Temperature Dependence Kim, Jisoo Son, Changjin Choi, Sunjak Yoon, Won Jung Ju, Heongkyu Micromachines (Basel) Article We present the plasmonic fiber based optical glucometer. A thin gold layer is coated on clad-free core of multimode optical fiber along 3 cm length to excite surface plasmons at 632.8 nm wavelength. Glucose oxidase is immobilized on the metal surface for glucose sensing. The effective surface refractive index increases by gluconic acid and hydrogen peroxide that are generated upon glucose injection, leading to plasmonic condition change with a consequence of optical power change at the fiber output. We obtain limit of detection of glucose concentration of 6.75 mg/dL, indicating higher sensitivity than the wavelength interrogating SPR glucometer that uses a spectrometer of 1nm spectral resolution. The coefficient of variation is 8.6% at a glucose concentration of 80 mg/dL at room temperature. We also examine the effects of ambient temperature variations from −10 °C to 40 °C on the performance of the presented sensor and compared them with those on commercially available glucometers that are based on enzyme electrodes. We find that the presented fiber sensor produced standard deviation of 12.1 mg/dL at a glucose concentration of 80 mg/dL under such varying temperature, which is, even without additional temperature correction function, comparable to the commercialized ones. MDPI 2018-10-05 /pmc/articles/PMC6215121/ /pubmed/30424439 http://dx.doi.org/10.3390/mi9100506 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Jisoo
Son, Changjin
Choi, Sunjak
Yoon, Won Jung
Ju, Heongkyu
A Plasmonic Fiber Based Glucometer and Its Temperature Dependence
title A Plasmonic Fiber Based Glucometer and Its Temperature Dependence
title_full A Plasmonic Fiber Based Glucometer and Its Temperature Dependence
title_fullStr A Plasmonic Fiber Based Glucometer and Its Temperature Dependence
title_full_unstemmed A Plasmonic Fiber Based Glucometer and Its Temperature Dependence
title_short A Plasmonic Fiber Based Glucometer and Its Temperature Dependence
title_sort plasmonic fiber based glucometer and its temperature dependence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215121/
https://www.ncbi.nlm.nih.gov/pubmed/30424439
http://dx.doi.org/10.3390/mi9100506
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