Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

There is an unmet need for economical snakebite therapies with long shelf lives that are effective even with delays in treatment. The orally bioavailable, heat-stable, secretory phospholipase A(2) (sPLA(2)) inhibitor, LY333013, demonstrates antidotal characteristics for severe snakebite envenoming i...

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Detalles Bibliográficos
Autores principales: Lewin, Matthew R., Gutiérrez, José María, Samuel, Stephen P., Herrera, María, Bryan-Quirós, Wendy, Lomonte, Bruno, Bickler, Philip E., Bulfone, Tommaso C., Williams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215158/
https://www.ncbi.nlm.nih.gov/pubmed/30241297
http://dx.doi.org/10.3390/toxins10100380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215158/
https://www.ncbi.nlm.nih.gov/pubmed/30241297
http://dx.doi.org/10.3390/toxins10100380

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