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Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs

Microelectrode arrays that consistently and reliably record and stimulate neural activity under conditions of chronic implantation have so far eluded the neural interface community due to failures attributed to both biotic and abiotic mechanisms. Arrays with transverse dimensions of 10 µm or below a...

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Autores principales: Deku, Felix, Frewin, Christopher L., Stiller, Allison, Cohen, Yarden, Aqeel, Saher, Joshi-Imre, Alexandra, Black, Bryan, Gardner, Timothy J., Pancrazio, Joseph J., Cogan, Stuart F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215182/
https://www.ncbi.nlm.nih.gov/pubmed/30424413
http://dx.doi.org/10.3390/mi9100480
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author Deku, Felix
Frewin, Christopher L.
Stiller, Allison
Cohen, Yarden
Aqeel, Saher
Joshi-Imre, Alexandra
Black, Bryan
Gardner, Timothy J.
Pancrazio, Joseph J.
Cogan, Stuart F.
author_facet Deku, Felix
Frewin, Christopher L.
Stiller, Allison
Cohen, Yarden
Aqeel, Saher
Joshi-Imre, Alexandra
Black, Bryan
Gardner, Timothy J.
Pancrazio, Joseph J.
Cogan, Stuart F.
author_sort Deku, Felix
collection PubMed
description Microelectrode arrays that consistently and reliably record and stimulate neural activity under conditions of chronic implantation have so far eluded the neural interface community due to failures attributed to both biotic and abiotic mechanisms. Arrays with transverse dimensions of 10 µm or below are thought to minimize the inflammatory response; however, the reduction of implant thickness also decreases buckling thresholds for materials with low Young’s modulus. While these issues have been overcome using stiffer, thicker materials as transport shuttles during implantation, the acute damage from the use of shuttles may generate many other biotic complications. Amorphous silicon carbide (a-SiC) provides excellent electrical insulation and a large Young’s modulus, allowing the fabrication of ultrasmall arrays with increased resistance to buckling. Prototype a-SiC intracortical implants were fabricated containing 8 - 16 single shanks which had critical thicknesses of either 4 µm or 6 µm. The 6 µm thick a-SiC shanks could penetrate rat cortex without an insertion aid. Single unit recordings from SIROF-coated arrays implanted without any structural support are presented. This work demonstrates that a-SiC can provide an excellent mechanical platform for devices that penetrate cortical tissue while maintaining a critical thickness less than 10 µm.
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spelling pubmed-62151822018-11-06 Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs Deku, Felix Frewin, Christopher L. Stiller, Allison Cohen, Yarden Aqeel, Saher Joshi-Imre, Alexandra Black, Bryan Gardner, Timothy J. Pancrazio, Joseph J. Cogan, Stuart F. Micromachines (Basel) Article Microelectrode arrays that consistently and reliably record and stimulate neural activity under conditions of chronic implantation have so far eluded the neural interface community due to failures attributed to both biotic and abiotic mechanisms. Arrays with transverse dimensions of 10 µm or below are thought to minimize the inflammatory response; however, the reduction of implant thickness also decreases buckling thresholds for materials with low Young’s modulus. While these issues have been overcome using stiffer, thicker materials as transport shuttles during implantation, the acute damage from the use of shuttles may generate many other biotic complications. Amorphous silicon carbide (a-SiC) provides excellent electrical insulation and a large Young’s modulus, allowing the fabrication of ultrasmall arrays with increased resistance to buckling. Prototype a-SiC intracortical implants were fabricated containing 8 - 16 single shanks which had critical thicknesses of either 4 µm or 6 µm. The 6 µm thick a-SiC shanks could penetrate rat cortex without an insertion aid. Single unit recordings from SIROF-coated arrays implanted without any structural support are presented. This work demonstrates that a-SiC can provide an excellent mechanical platform for devices that penetrate cortical tissue while maintaining a critical thickness less than 10 µm. MDPI 2018-09-20 /pmc/articles/PMC6215182/ /pubmed/30424413 http://dx.doi.org/10.3390/mi9100480 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Deku, Felix
Frewin, Christopher L.
Stiller, Allison
Cohen, Yarden
Aqeel, Saher
Joshi-Imre, Alexandra
Black, Bryan
Gardner, Timothy J.
Pancrazio, Joseph J.
Cogan, Stuart F.
Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs
title Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs
title_full Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs
title_fullStr Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs
title_full_unstemmed Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs
title_short Amorphous Silicon Carbide Platform for Next Generation Penetrating Neural Interface Designs
title_sort amorphous silicon carbide platform for next generation penetrating neural interface designs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215182/
https://www.ncbi.nlm.nih.gov/pubmed/30424413
http://dx.doi.org/10.3390/mi9100480
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