Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals

Unique divergence of the BRCA2, a tumor suppressor gene, in Neanderthals relative to other primates, including modern humans, is highlighted. This divergence with potentially pathogenic consequences raises a question about cancer susceptibility in the archaic species that was replaced by modern huma...

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Detalles Bibliográficos
Autores principales: Michalak, Pawel, Kang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215347/
https://www.ncbi.nlm.nih.gov/pubmed/30410429
http://dx.doi.org/10.1186/s41065-018-0073-5
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author Michalak, Pawel
Kang, Lin
author_facet Michalak, Pawel
Kang, Lin
author_sort Michalak, Pawel
collection PubMed
description Unique divergence of the BRCA2, a tumor suppressor gene, in Neanderthals relative to other primates, including modern humans, is highlighted. This divergence with potentially pathogenic consequences raises a question about cancer susceptibility in the archaic species that was replaced by modern humans about 40,000 years ago.
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spelling pubmed-62153472018-11-08 Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals Michalak, Pawel Kang, Lin Hereditas Letter to the Editor Unique divergence of the BRCA2, a tumor suppressor gene, in Neanderthals relative to other primates, including modern humans, is highlighted. This divergence with potentially pathogenic consequences raises a question about cancer susceptibility in the archaic species that was replaced by modern humans about 40,000 years ago. BioMed Central 2018-11-03 /pmc/articles/PMC6215347/ /pubmed/30410429 http://dx.doi.org/10.1186/s41065-018-0073-5 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Michalak, Pawel
Kang, Lin
Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals
title Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals
title_full Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals
title_fullStr Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals
title_full_unstemmed Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals
title_short Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals
title_sort unique divergence of the breast cancer 2 (brca2) gene in neanderthals
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215347/
https://www.ncbi.nlm.nih.gov/pubmed/30410429
http://dx.doi.org/10.1186/s41065-018-0073-5
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