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Chromosomal instability causes sensitivity to protein folding stress and ATP depletion
Aneuploidy ()– having an unbalanced genome – is poorly tolerated at the cellular and organismal level. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift which makes these cells sensitive to internal and environmental stresses. Using Drosophila as a model, we found that...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215417/ https://www.ncbi.nlm.nih.gov/pubmed/30327366 http://dx.doi.org/10.1242/bio.038000 |