Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field

The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impa...

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Detalles Bibliográficos
Autores principales: Peterson, Joshua C., Chughtai, Mary, Wisse, Lambertus J., Gittenberger-de Groot, Adriana C., Feng, Qingping, Goumans, Marie-José T. H., VanMunsteren, J. Conny, Jongbloed, Monique R. M., DeRuiter, Marco C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215433/
https://www.ncbi.nlm.nih.gov/pubmed/30242109
http://dx.doi.org/10.1242/dmm.034637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215433/
https://www.ncbi.nlm.nih.gov/pubmed/30242109
http://dx.doi.org/10.1242/dmm.034637

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