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Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field
The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impa...
Autores principales: | Peterson, Joshua C., Chughtai, Mary, Wisse, Lambertus J., Gittenberger-de Groot, Adriana C., Feng, Qingping, Goumans, Marie-José T. H., VanMunsteren, J. Conny, Jongbloed, Monique R. M., DeRuiter, Marco C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215433/ https://www.ncbi.nlm.nih.gov/pubmed/30242109 http://dx.doi.org/10.1242/dmm.034637 |
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