Cargando…

The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis

OBJECTIVES: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients. METHOD: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy can...

Descripción completa

Detalles Bibliográficos
Autores principales: Reitblat, Olga, Lerman, Tsahi T., Cohen, Ornit, Reitblat, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215561/
https://www.ncbi.nlm.nih.gov/pubmed/30420888
http://dx.doi.org/10.1155/2018/2586916
_version_ 1783368163194306560
author Reitblat, Olga
Lerman, Tsahi T.
Cohen, Ornit
Reitblat, Tatiana
author_facet Reitblat, Olga
Lerman, Tsahi T.
Cohen, Ornit
Reitblat, Tatiana
author_sort Reitblat, Olga
collection PubMed
description OBJECTIVES: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients. METHOD: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy candidates. TST measurements, prednisone and methotrexate dosages, and treatment durations were recorded. A control group was randomly selected from healthy subjects. We compared TST reaction size between the following three groups: RA patients with current prednisone treatment, RA prednisone naïve patients, and healthy individuals. RESULTS: Our study sample comprised 43 RA patients with prednisone treatment, 22 prednisone naïve patients, and 195 healthy subjects. There was no significant difference in mean TST between the groups (5.3±6.6, 7.8±6.2, and 7.6±7.0, respectively, p=0.149). No correlation was noted between TST size and prednisone u-y (r=0.229, p=0.140) or methotrexate u-y in patients with and without prednisone therapy (r=0.219, p=0.158; and r=−0.293, p=0.186, respectively). CONCLUSIONS: Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated.
format Online
Article
Text
id pubmed-6215561
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-62155612018-11-12 The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis Reitblat, Olga Lerman, Tsahi T. Cohen, Ornit Reitblat, Tatiana Int J Rheumatol Research Article OBJECTIVES: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients. METHOD: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy candidates. TST measurements, prednisone and methotrexate dosages, and treatment durations were recorded. A control group was randomly selected from healthy subjects. We compared TST reaction size between the following three groups: RA patients with current prednisone treatment, RA prednisone naïve patients, and healthy individuals. RESULTS: Our study sample comprised 43 RA patients with prednisone treatment, 22 prednisone naïve patients, and 195 healthy subjects. There was no significant difference in mean TST between the groups (5.3±6.6, 7.8±6.2, and 7.6±7.0, respectively, p=0.149). No correlation was noted between TST size and prednisone u-y (r=0.229, p=0.140) or methotrexate u-y in patients with and without prednisone therapy (r=0.219, p=0.158; and r=−0.293, p=0.186, respectively). CONCLUSIONS: Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated. Hindawi 2018-10-21 /pmc/articles/PMC6215561/ /pubmed/30420888 http://dx.doi.org/10.1155/2018/2586916 Text en Copyright © 2018 Olga Reitblat et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Reitblat, Olga
Lerman, Tsahi T.
Cohen, Ornit
Reitblat, Tatiana
The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
title The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
title_full The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
title_fullStr The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
title_full_unstemmed The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
title_short The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
title_sort effect of prednisone on tuberculin skin test reaction in patients with rheumatoid arthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215561/
https://www.ncbi.nlm.nih.gov/pubmed/30420888
http://dx.doi.org/10.1155/2018/2586916
work_keys_str_mv AT reitblatolga theeffectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis
AT lermantsahit theeffectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis
AT cohenornit theeffectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis
AT reitblattatiana theeffectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis
AT reitblatolga effectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis
AT lermantsahit effectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis
AT cohenornit effectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis
AT reitblattatiana effectofprednisoneontuberculinskintestreactioninpatientswithrheumatoidarthritis