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The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis
OBJECTIVES: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients. METHOD: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy can...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215561/ https://www.ncbi.nlm.nih.gov/pubmed/30420888 http://dx.doi.org/10.1155/2018/2586916 |
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author | Reitblat, Olga Lerman, Tsahi T. Cohen, Ornit Reitblat, Tatiana |
author_facet | Reitblat, Olga Lerman, Tsahi T. Cohen, Ornit Reitblat, Tatiana |
author_sort | Reitblat, Olga |
collection | PubMed |
description | OBJECTIVES: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients. METHOD: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy candidates. TST measurements, prednisone and methotrexate dosages, and treatment durations were recorded. A control group was randomly selected from healthy subjects. We compared TST reaction size between the following three groups: RA patients with current prednisone treatment, RA prednisone naïve patients, and healthy individuals. RESULTS: Our study sample comprised 43 RA patients with prednisone treatment, 22 prednisone naïve patients, and 195 healthy subjects. There was no significant difference in mean TST between the groups (5.3±6.6, 7.8±6.2, and 7.6±7.0, respectively, p=0.149). No correlation was noted between TST size and prednisone u-y (r=0.229, p=0.140) or methotrexate u-y in patients with and without prednisone therapy (r=0.219, p=0.158; and r=−0.293, p=0.186, respectively). CONCLUSIONS: Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated. |
format | Online Article Text |
id | pubmed-6215561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-62155612018-11-12 The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis Reitblat, Olga Lerman, Tsahi T. Cohen, Ornit Reitblat, Tatiana Int J Rheumatol Research Article OBJECTIVES: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients. METHOD: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy candidates. TST measurements, prednisone and methotrexate dosages, and treatment durations were recorded. A control group was randomly selected from healthy subjects. We compared TST reaction size between the following three groups: RA patients with current prednisone treatment, RA prednisone naïve patients, and healthy individuals. RESULTS: Our study sample comprised 43 RA patients with prednisone treatment, 22 prednisone naïve patients, and 195 healthy subjects. There was no significant difference in mean TST between the groups (5.3±6.6, 7.8±6.2, and 7.6±7.0, respectively, p=0.149). No correlation was noted between TST size and prednisone u-y (r=0.229, p=0.140) or methotrexate u-y in patients with and without prednisone therapy (r=0.219, p=0.158; and r=−0.293, p=0.186, respectively). CONCLUSIONS: Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated. Hindawi 2018-10-21 /pmc/articles/PMC6215561/ /pubmed/30420888 http://dx.doi.org/10.1155/2018/2586916 Text en Copyright © 2018 Olga Reitblat et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Reitblat, Olga Lerman, Tsahi T. Cohen, Ornit Reitblat, Tatiana The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis |
title | The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis |
title_full | The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis |
title_fullStr | The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis |
title_full_unstemmed | The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis |
title_short | The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis |
title_sort | effect of prednisone on tuberculin skin test reaction in patients with rheumatoid arthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215561/ https://www.ncbi.nlm.nih.gov/pubmed/30420888 http://dx.doi.org/10.1155/2018/2586916 |
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