Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma: Clinical Application to Therapeutic Drug Monitoring

A rapid and selective UPLC-DAD method was developed and validated for simultaneous analysis of the novel two-drug combination Darvoni® for the treatment of HCV: Sofosbuvir (SF)/Daclatasvir (DC) in human plasma using Ledipasvir as internal standard (IS) where the extraction process was conducted usin...

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Detalles Bibliográficos
Autores principales: Al-Tannak, Naser F., Hemdan, Ahmed, Eissa, Maya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215565/
https://www.ncbi.nlm.nih.gov/pubmed/30420886
http://dx.doi.org/10.1155/2018/6535816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215565/
https://www.ncbi.nlm.nih.gov/pubmed/30420886
http://dx.doi.org/10.1155/2018/6535816

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