Cargando…

Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating Akt/mTOR Signaling

Insulin resistance has a critical role in type 2 diabetes. The aim of this study was to investigate the effect of pinobanksin, galangin, chrysin, and pinocembrin from propolis on insulin resistance. Our study shows that galangin and pinocembrin can ameliorate insulin resistance; on the contrary, pin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yinkang, Liang, Xiali, Zhang, Gensheng, Kong, Lingjie, Peng, Wenjun, Zhang, Hongcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215570/ https://www.ncbi.nlm.nih.gov/pubmed/30420897 http://dx.doi.org/10.1155/2018/7971842

Ejemplares similares

Multifunctional selenium nanoparticles with Galangin-induced HepG2 cell apoptosis through p38 and AKT signalling pathway
por: Li, Yinghua, et al.
Publicado: (2018)

Galangin Induces Autophagy via Deacetylation of LC3 by SIRT1 in HepG2 Cells
por: Li, Xv, et al.
Publicado: (2016)

Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy
por: Granados-Pineda, Jessica, et al.
Publicado: (2018)

Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells
por: Hu, Huiling, et al.
Publicado: (2022)

Genistein Regulates Lipid Metabolism via Estrogen Receptor β and Its Downstream Signal Akt/mTOR in HepG2 Cells
por: Qin, Hong, et al.
Publicado: (2021)

Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway
por: Xie, Hai, et al.
Publicado: (2022)

RagC GTPase regulates mTOR to promote chemoresistance in senescence-like HepG2 cells
por: Jiang, Wei, et al.
Publicado: (2022)

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
por: Zhang, Chao, et al.
Publicado: (2016)

Celastrus orbiculatus extracts induce apoptosis in mTOR-overexpressed human hepatocellular carcinoma HepG2 cells
por: Qian, Yayun, et al.
Publicado: (2018)

Pinocembrin ameliorates arrhythmias in rats with chronic ischaemic heart failure
por: Guo, Yan, et al.
Publicado: (2021)

Theoretical Insights into the Oxidative Stress-Relieving Properties of Pinocembrin—An Isolated Flavonoid from Honey and Propolis
por: Spiegel, Maciej
Publicado: (2023)

Application of Visible and Near Infrared Spectroscopy for Rapid Analysis of Chrysin and Galangin in Chinese Propolis
por: Nie, Pengcheng, et al.
Publicado: (2013)

Phenolic Compounds of Propolis Alleviate Lipid Metabolism Disorder
por: Kong, Lingjie, et al.
Publicado: (2021)

Polyphenols from Chilean Propolis and Pinocembrin Reduce MMP-9 Gene Expression and Activity in Activated Macrophages
por: Saavedra, Nicolás, et al.
Publicado: (2016)

Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line
por: Rial, Sabri Ahmed, et al.
Publicado: (2018)

Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells
por: Chien, Shang-Tao, et al.
Publicado: (2015)

Nifuroxazide ameliorates lipid and glucose metabolism in palmitate-induced HepG2 cells
por: Liu, Jing-Yi, et al.
Publicado: (2019)

Botanical Origins and Antioxidant Activities of Two Types of Flavonoid-Rich Poplar-Type Propolis
por: Qiao, Jiangtao, et al.
Publicado: (2023)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells
por: Kim, Seong Min, et al.
Publicado: (2020)

Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF-β1 Signaling Pathway
por: Li, Xiaohe, et al.
Publicado: (2021)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation
por: Ran, Qian, et al.
Publicado: (2022)

Kangtaizhi Granule Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats and HepG2 Cells via AMPK/mTOR Signaling Pathway
por: Zhang, Jiaxin, et al.
Publicado: (2020)

Simvastatin ameliorates oxidative stress levels in HepG2 cells and hyperlipidemic rats
por: Verma, Kanika, et al.
Publicado: (2022)

Galangin ameliorates cardiac remodeling via the MEK1/2–ERK1/2 and PI3K–AKT pathways
por: Wang, Hui‐Bo, et al.
Publicado: (2019)

Pinocembrin ameliorates lipopolysaccharide-induced HK-2 cell apoptosis and inflammation by regulating endoplasmic reticulum stress
por: Zhang, Yu, et al.
Publicado: (2022)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells
por: Zhou, Youping, et al.
Publicado: (2018)

Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway
por: Gao, Yan, et al.
Publicado: (2019)

Optimization of Pinocembrin Biosynthesis in Saccharomyces cerevisiae
por: Tous Mohedano, Marta, et al.
Publicado: (2022)

The Anti-Campylobacter Activity and Mechanisms of Pinocembrin Action
por: Klančnik, Anja, et al.
Publicado: (2019)

Spirulina platensis Ameliorates Oxidative Stress Associated with Antiretroviral Drugs in HepG2 Cells
por: Sibiya, Thabani, et al.
Publicado: (2022)

Antioxidant properties of bee propolis and an important component, galangin, described by X-ray crystal structure, DFT-D and hydrodynamic voltammetry
por: Caruso, Francesco, et al.
Publicado: (2022)

Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-α/PI3K/Akt-Signaling Pathways in HepG2 Cells
por: Fang, Ke, et al.
Publicado: (2016)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

miR-214 ameliorates sepsis-induced acute kidney injury via PTEN/AKT/mTOR-regulated autophagy
por: Sang, Zhenzhen, et al.
Publicado: (2021)

Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF‐κB signaling
por: Feng, Yuan, et al.
Publicado: (2023)

Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway
por: Chen, Xiuhuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4vc4e5iupjsi5evss6m3jhh99r