Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling

Recent data has shown that cyclin G2 (CCNG2) is an atypical cyclin that inhibits cell cycle progression and is often dysregulated in human cancers. The involvement of cyclin G2 in the occurrence and development of diabetic nephropathy (DN) has not been determined. In the present study, we conducted...

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Autores principales: Zhao, Chenyang, Gao, Jinlan, Li, Sen, Liu, Qi, Hou, Xiaoyu, Liu, Shenghuan, Xing, Xuesha, Sun, Manni, Wang, Shusen, Luo, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215590/
https://www.ncbi.nlm.nih.gov/pubmed/30420966
http://dx.doi.org/10.1155/2018/6938482
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author Zhao, Chenyang
Gao, Jinlan
Li, Sen
Liu, Qi
Hou, Xiaoyu
Liu, Shenghuan
Xing, Xuesha
Sun, Manni
Wang, Shusen
Luo, Yang
author_facet Zhao, Chenyang
Gao, Jinlan
Li, Sen
Liu, Qi
Hou, Xiaoyu
Liu, Shenghuan
Xing, Xuesha
Sun, Manni
Wang, Shusen
Luo, Yang
author_sort Zhao, Chenyang
collection PubMed
description Recent data has shown that cyclin G2 (CCNG2) is an atypical cyclin that inhibits cell cycle progression and is often dysregulated in human cancers. The involvement of cyclin G2 in the occurrence and development of diabetic nephropathy (DN) has not been determined. In the present study, we conducted cyclin G2 knockout studies to determine whether this protein regulates glomerulosclerosis in DN mice. We found that cyclin G2 regulated the expression of renal glomerulosclerosis-related proteins via the canonical Wnt signalling pathway in glomerular mesangial cells. A cyclin G2 deficiency resulted in more severe renal injury in DN mice. These findings provided new insight into the pathogenesis of DN, revealing that cyclin G2 has a protective role in glomerulosclerosis and is a potential new target for the prevention and treatment of DN.
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spelling pubmed-62155902018-11-12 Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling Zhao, Chenyang Gao, Jinlan Li, Sen Liu, Qi Hou, Xiaoyu Liu, Shenghuan Xing, Xuesha Sun, Manni Wang, Shusen Luo, Yang Biomed Res Int Research Article Recent data has shown that cyclin G2 (CCNG2) is an atypical cyclin that inhibits cell cycle progression and is often dysregulated in human cancers. The involvement of cyclin G2 in the occurrence and development of diabetic nephropathy (DN) has not been determined. In the present study, we conducted cyclin G2 knockout studies to determine whether this protein regulates glomerulosclerosis in DN mice. We found that cyclin G2 regulated the expression of renal glomerulosclerosis-related proteins via the canonical Wnt signalling pathway in glomerular mesangial cells. A cyclin G2 deficiency resulted in more severe renal injury in DN mice. These findings provided new insight into the pathogenesis of DN, revealing that cyclin G2 has a protective role in glomerulosclerosis and is a potential new target for the prevention and treatment of DN. Hindawi 2018-10-21 /pmc/articles/PMC6215590/ /pubmed/30420966 http://dx.doi.org/10.1155/2018/6938482 Text en Copyright © 2018 Chenyang Zhao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhao, Chenyang
Gao, Jinlan
Li, Sen
Liu, Qi
Hou, Xiaoyu
Liu, Shenghuan
Xing, Xuesha
Sun, Manni
Wang, Shusen
Luo, Yang
Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
title Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
title_full Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
title_fullStr Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
title_full_unstemmed Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
title_short Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
title_sort cyclin g2 suppresses glomerulosclerosis by regulating canonical wnt signalling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215590/
https://www.ncbi.nlm.nih.gov/pubmed/30420966
http://dx.doi.org/10.1155/2018/6938482
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