Cargando…

First-reported pediatric cases of American ginseng anaphylaxis and allergy

BACKGROUND: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng). Although...

Descripción completa

Detalles Bibliográficos
Autores principales: Erdle, Stephanie C., Chan, Edmond S., Yang, Hyungjun, Vallance, Bruce A., Mill, Christopher, Wong, Tiffany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215653/
https://www.ncbi.nlm.nih.gov/pubmed/30410551
http://dx.doi.org/10.1186/s13223-018-0304-3
_version_ 1783368185600278528
author Erdle, Stephanie C.
Chan, Edmond S.
Yang, Hyungjun
Vallance, Bruce A.
Mill, Christopher
Wong, Tiffany
author_facet Erdle, Stephanie C.
Chan, Edmond S.
Yang, Hyungjun
Vallance, Bruce A.
Mill, Christopher
Wong, Tiffany
author_sort Erdle, Stephanie C.
collection PubMed
description BACKGROUND: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng, and no reported cases of ginseng allergy in pediatric patients. CASE PRESENTATION: We present two unique cases of pediatric patients with suspected allergic reactions to American ginseng. The first patient is a 6-year-old girl who presented to the emergency department in anaphylaxis (urticaria and respiratory symptoms) minutes after inhaling powdered American ginseng. There was evidence of sensitization to American ginseng on skin prick testing (SPT) (13 × 12 mm wheal) and evidence of allergy to American ginseng on basophil activation testing, with a dose-dependent increase in expression of CD63 on basophils in response to American ginseng extract. The second patient is a 3-year-old boy who presented with recurrent allergic conjunctivitis upon exposure to aerosolized powdered ginseng, with evidence of sensitization to American ginseng on SPT (13 × 7 mm wheal), but with no evidence of IgE-mediated allergic reaction during oral challenge with American ginseng powder. CONCLUSIONS: These cases highlight two different allergic responses to American ginseng in pediatric patients. To our knowledge, these are the first reported cases of allergy to American ginseng, in addition to the first reported cases of allergy to ginseng in pediatric patients.
format Online
Article
Text
id pubmed-6215653
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-62156532018-11-08 First-reported pediatric cases of American ginseng anaphylaxis and allergy Erdle, Stephanie C. Chan, Edmond S. Yang, Hyungjun Vallance, Bruce A. Mill, Christopher Wong, Tiffany Allergy Asthma Clin Immunol Case Report BACKGROUND: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Korean or Asian ginseng), and Panax quinquefolius (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng, and no reported cases of ginseng allergy in pediatric patients. CASE PRESENTATION: We present two unique cases of pediatric patients with suspected allergic reactions to American ginseng. The first patient is a 6-year-old girl who presented to the emergency department in anaphylaxis (urticaria and respiratory symptoms) minutes after inhaling powdered American ginseng. There was evidence of sensitization to American ginseng on skin prick testing (SPT) (13 × 12 mm wheal) and evidence of allergy to American ginseng on basophil activation testing, with a dose-dependent increase in expression of CD63 on basophils in response to American ginseng extract. The second patient is a 3-year-old boy who presented with recurrent allergic conjunctivitis upon exposure to aerosolized powdered ginseng, with evidence of sensitization to American ginseng on SPT (13 × 7 mm wheal), but with no evidence of IgE-mediated allergic reaction during oral challenge with American ginseng powder. CONCLUSIONS: These cases highlight two different allergic responses to American ginseng in pediatric patients. To our knowledge, these are the first reported cases of allergy to American ginseng, in addition to the first reported cases of allergy to ginseng in pediatric patients. BioMed Central 2018-11-03 /pmc/articles/PMC6215653/ /pubmed/30410551 http://dx.doi.org/10.1186/s13223-018-0304-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Erdle, Stephanie C.
Chan, Edmond S.
Yang, Hyungjun
Vallance, Bruce A.
Mill, Christopher
Wong, Tiffany
First-reported pediatric cases of American ginseng anaphylaxis and allergy
title First-reported pediatric cases of American ginseng anaphylaxis and allergy
title_full First-reported pediatric cases of American ginseng anaphylaxis and allergy
title_fullStr First-reported pediatric cases of American ginseng anaphylaxis and allergy
title_full_unstemmed First-reported pediatric cases of American ginseng anaphylaxis and allergy
title_short First-reported pediatric cases of American ginseng anaphylaxis and allergy
title_sort first-reported pediatric cases of american ginseng anaphylaxis and allergy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215653/
https://www.ncbi.nlm.nih.gov/pubmed/30410551
http://dx.doi.org/10.1186/s13223-018-0304-3
work_keys_str_mv AT erdlestephaniec firstreportedpediatriccasesofamericanginsenganaphylaxisandallergy
AT chanedmonds firstreportedpediatriccasesofamericanginsenganaphylaxisandallergy
AT yanghyungjun firstreportedpediatriccasesofamericanginsenganaphylaxisandallergy
AT vallancebrucea firstreportedpediatriccasesofamericanginsenganaphylaxisandallergy
AT millchristopher firstreportedpediatriccasesofamericanginsenganaphylaxisandallergy
AT wongtiffany firstreportedpediatriccasesofamericanginsenganaphylaxisandallergy