Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect

BACKGROUND: Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown. METHODS: We generated a T2D mouse model by using high-fat-diet (HFD) and Streptozotocin (STZ) injection. We examined mtDNA mutations in oocy...

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Detalles Bibliográficos
Autores principales: Li, Li, Wu, Chang-Sheng, Hou, Guan-Mei, Dong, Ming-Zhe, Wang, Zhen-Bo, Hou, Yi, Schatten, Heide, Zhang, Gui-Rong, Sun, Qing-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215660/
https://www.ncbi.nlm.nih.gov/pubmed/30390692
http://dx.doi.org/10.1186/s12958-018-0423-1

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