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Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation
BACKGROUND: Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impact of left ventricular (LV) remodeling on the presence of AF in HCM patients has...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215688/ https://www.ncbi.nlm.nih.gov/pubmed/30390664 http://dx.doi.org/10.1186/s12872-018-0945-7 |
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author | Tian, Hongwei Cui, Jingang Yang, Chengzhi Hu, Fenghuan Yuan, Jiansong Liu, Shengwen Yang, Weixian Jiang, Xiaowei Qiao, Shubin |
author_facet | Tian, Hongwei Cui, Jingang Yang, Chengzhi Hu, Fenghuan Yuan, Jiansong Liu, Shengwen Yang, Weixian Jiang, Xiaowei Qiao, Shubin |
author_sort | Tian, Hongwei |
collection | PubMed |
description | BACKGROUND: Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impact of left ventricular (LV) remodeling on the presence of AF in HCM patients has not been evaluated yet. We sought to investigate effect of LV remodeling on the presence of AF assessed by cardiovascular magnetic resonance (CMR) in HCM patients. METHODS: A total of 394 HCM patients were enrolled into this study, including HOCM patients (n = 293) and NOHCM patients (n = 101). Patients were divided into HCM with AF (50) and HCM without AF (n = 344). Data were collected from hospital records. RESULTS: LA diameter and LV remodeling index (LVRI) were significantly higher in HCM patients with AF than that of HCM patients without AF (46.6 ± 7.4 mm versus 39.9 ± 8.0 mm, p < 0.001, and 1.46 ± 0.6 versus 1.2 ± 0.4, p = 0.002, respectively). HCM patients with AF were older than HCM patients without AF (53.6 ± 11.7 years versus 47.7 ± 13.6 years, p = 0.002). Additionally, LVRI positively correlated to LA size (r = 0.12, p = 0.02). In a multivariable logistic regression analysis, when adjusting for age and LV end diastolic mass index, LVRI and LA size remained an independent determinant of AF in HCM patients (OR = 4.7, p = 0.001 and OR = 1.13, P < 0.001). CONCLUSION: HCM patients with AF showed significantly more LA diameter, LVRI and age than HCM patients without AF. LVRI and LA size were strong independent predictor of AF in HCM, suggesting LV remodeling may contribute to the occurrence of AF in HCM patients. |
format | Online Article Text |
id | pubmed-6215688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62156882018-11-08 Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation Tian, Hongwei Cui, Jingang Yang, Chengzhi Hu, Fenghuan Yuan, Jiansong Liu, Shengwen Yang, Weixian Jiang, Xiaowei Qiao, Shubin BMC Cardiovasc Disord Research Article BACKGROUND: Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impact of left ventricular (LV) remodeling on the presence of AF in HCM patients has not been evaluated yet. We sought to investigate effect of LV remodeling on the presence of AF assessed by cardiovascular magnetic resonance (CMR) in HCM patients. METHODS: A total of 394 HCM patients were enrolled into this study, including HOCM patients (n = 293) and NOHCM patients (n = 101). Patients were divided into HCM with AF (50) and HCM without AF (n = 344). Data were collected from hospital records. RESULTS: LA diameter and LV remodeling index (LVRI) were significantly higher in HCM patients with AF than that of HCM patients without AF (46.6 ± 7.4 mm versus 39.9 ± 8.0 mm, p < 0.001, and 1.46 ± 0.6 versus 1.2 ± 0.4, p = 0.002, respectively). HCM patients with AF were older than HCM patients without AF (53.6 ± 11.7 years versus 47.7 ± 13.6 years, p = 0.002). Additionally, LVRI positively correlated to LA size (r = 0.12, p = 0.02). In a multivariable logistic regression analysis, when adjusting for age and LV end diastolic mass index, LVRI and LA size remained an independent determinant of AF in HCM patients (OR = 4.7, p = 0.001 and OR = 1.13, P < 0.001). CONCLUSION: HCM patients with AF showed significantly more LA diameter, LVRI and age than HCM patients without AF. LVRI and LA size were strong independent predictor of AF in HCM, suggesting LV remodeling may contribute to the occurrence of AF in HCM patients. BioMed Central 2018-11-03 /pmc/articles/PMC6215688/ /pubmed/30390664 http://dx.doi.org/10.1186/s12872-018-0945-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Tian, Hongwei Cui, Jingang Yang, Chengzhi Hu, Fenghuan Yuan, Jiansong Liu, Shengwen Yang, Weixian Jiang, Xiaowei Qiao, Shubin Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
title | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
title_full | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
title_fullStr | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
title_full_unstemmed | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
title_short | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
title_sort | left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215688/ https://www.ncbi.nlm.nih.gov/pubmed/30390664 http://dx.doi.org/10.1186/s12872-018-0945-7 |
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