NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward

The diurnal regulation of dopamine is important for normal physiology and diseases such as addiction. Here we find a novel role for the CLOCK protein to antagonize CREB-mediated transcriptional activity at the tyrosine hydroxylase (TH) promoter, which is mediated by the interaction with the metaboli...

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Detalles Bibliográficos
Autores principales: Logan, Ryan W., Parekh, Puja K., Kaplan, Gabrielle, Becker-Krail, Darius, Williams, Wilbur, Yamaguchi, Shintaro, Yoshino, Jun, Shelton, Micah A., Zhu, Xiyu, Zhang, Hui, Waplinger, Spencer, Fitzgerald, Ethan, Oliver-Smith, Jeffrey, Sundarvelu, Poornima, Enwright, John F., Huang, Yanhua H., McClung, Colleen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215755/
https://www.ncbi.nlm.nih.gov/pubmed/29728703
http://dx.doi.org/10.1038/s41380-018-0061-1

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