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Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. PCOS has been associated with distinct metabolic and cardiovascular diseases and with autoimmune conditions, predominantly autoimmune thyroid disease (AITD). AITD has been reported in 18–40...

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Autores principales: Romitti, Mírian, Fabris, Vitor C, Ziegelmann, Patricia K, Maia, Ana Luiza, Spritzer, Poli Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215798/
https://www.ncbi.nlm.nih.gov/pubmed/30352422
http://dx.doi.org/10.1530/EC-18-0309
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author Romitti, Mírian
Fabris, Vitor C
Ziegelmann, Patricia K
Maia, Ana Luiza
Spritzer, Poli Mara
author_facet Romitti, Mírian
Fabris, Vitor C
Ziegelmann, Patricia K
Maia, Ana Luiza
Spritzer, Poli Mara
author_sort Romitti, Mírian
collection PubMed
description Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. PCOS has been associated with distinct metabolic and cardiovascular diseases and with autoimmune conditions, predominantly autoimmune thyroid disease (AITD). AITD has been reported in 18–40% of PCOS women, depending on PCOS diagnostic criteria and ethnicity. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding the likelihood of women with PCOS also having AITD in comparison to a reference group of non-PCOS women. We systematically searched EMBASE and MEDLINE for non-interventional case control, cross-sectional or cohort studies published until August 2017. The Ottawa–Newcastle Scale was used to assess the methodological quality of studies. Statistical meta-analysis was performed with R. Thirteen studies were selected for the present analysis, including 1210 women diagnosed with PCOS and 987 healthy controls. AITD was observed in 26.03 and 9.72% of PCOS and control groups respectively. A significant association was detected between PCOS and chance of AITD (OR = 3.27, 95% CI 2.32–4.63). Notably, after geographical stratification, the higher risk of AITD in PCOS women persisted for Asians (OR = 4.56, 95% CI 2.47–8.43), Europeans (OR = 3.27, 95% CI 2.07–5.15) and South Americans (OR = 1.86, 95% CI 1.05–3.29). AIDT is a frequent condition in PCOS patients and might affect thyroid function. Thus, screening for thyroid function and thyroid-specific autoantibodies should be considered in patients with PCOS even in the absence of overt symptoms. This systematic review and meta-analysis is registered in PROSPERO under number CRD42017079676.
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spelling pubmed-62157982018-11-07 Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis Romitti, Mírian Fabris, Vitor C Ziegelmann, Patricia K Maia, Ana Luiza Spritzer, Poli Mara Endocr Connect Research Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. PCOS has been associated with distinct metabolic and cardiovascular diseases and with autoimmune conditions, predominantly autoimmune thyroid disease (AITD). AITD has been reported in 18–40% of PCOS women, depending on PCOS diagnostic criteria and ethnicity. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding the likelihood of women with PCOS also having AITD in comparison to a reference group of non-PCOS women. We systematically searched EMBASE and MEDLINE for non-interventional case control, cross-sectional or cohort studies published until August 2017. The Ottawa–Newcastle Scale was used to assess the methodological quality of studies. Statistical meta-analysis was performed with R. Thirteen studies were selected for the present analysis, including 1210 women diagnosed with PCOS and 987 healthy controls. AITD was observed in 26.03 and 9.72% of PCOS and control groups respectively. A significant association was detected between PCOS and chance of AITD (OR = 3.27, 95% CI 2.32–4.63). Notably, after geographical stratification, the higher risk of AITD in PCOS women persisted for Asians (OR = 4.56, 95% CI 2.47–8.43), Europeans (OR = 3.27, 95% CI 2.07–5.15) and South Americans (OR = 1.86, 95% CI 1.05–3.29). AIDT is a frequent condition in PCOS patients and might affect thyroid function. Thus, screening for thyroid function and thyroid-specific autoantibodies should be considered in patients with PCOS even in the absence of overt symptoms. This systematic review and meta-analysis is registered in PROSPERO under number CRD42017079676. Bioscientifica Ltd 2018-09-10 /pmc/articles/PMC6215798/ /pubmed/30352422 http://dx.doi.org/10.1530/EC-18-0309 Text en © 2018 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research
Romitti, Mírian
Fabris, Vitor C
Ziegelmann, Patricia K
Maia, Ana Luiza
Spritzer, Poli Mara
Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis
title Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis
title_full Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis
title_fullStr Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis
title_full_unstemmed Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis
title_short Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis
title_sort association between pcos and autoimmune thyroid disease: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215798/
https://www.ncbi.nlm.nih.gov/pubmed/30352422
http://dx.doi.org/10.1530/EC-18-0309
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