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Antitumor effects of anlotinib in thyroid cancer
There is no effective treatment for patients with poorly differentiated papillary thyroid cancer or anaplastic thyroid cancer (ATC). Anlotinib, a multi-kinase inhibitor, has already shown antitumor effects in various types of carcinoma in a phase I clinical trial. In this study, we aimed to better u...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215907/ https://www.ncbi.nlm.nih.gov/pubmed/30139768 http://dx.doi.org/10.1530/ERC-17-0558 |
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author | Ruan, Xianhui Shi, Xianle Dong, Qiman Yu, Yang Hou, Xiukun Song, Xinhao Wei, Xi Chen, Lingyi Gao, Ming |
author_facet | Ruan, Xianhui Shi, Xianle Dong, Qiman Yu, Yang Hou, Xiukun Song, Xinhao Wei, Xi Chen, Lingyi Gao, Ming |
author_sort | Ruan, Xianhui |
collection | PubMed |
description | There is no effective treatment for patients with poorly differentiated papillary thyroid cancer or anaplastic thyroid cancer (ATC). Anlotinib, a multi-kinase inhibitor, has already shown antitumor effects in various types of carcinoma in a phase I clinical trial. In this study, we aimed to better understand the effect and efficacy of anlotinib against thyroid carcinoma cells in vitro and in vivo. We found that anlotinib inhibits the cell viability of papillary thyroid cancer and ATC cell lines, likely due to abnormal spindle assembly, G2/M arrest, and activation of TP53 upon anlotinib treatment. Moreover, anlotinib suppresses the migration of thyroid cancer cells in vitro and the growth of xenograft thyroid tumors in mice. Our data demonstrate that anlotinib has significant anticancer activity in thyroid cancer, and potentially offers an effective therapeutic strategy for patients of advanced thyroid cancer type. |
format | Online Article Text |
id | pubmed-6215907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62159072018-11-08 Antitumor effects of anlotinib in thyroid cancer Ruan, Xianhui Shi, Xianle Dong, Qiman Yu, Yang Hou, Xiukun Song, Xinhao Wei, Xi Chen, Lingyi Gao, Ming Endocr Relat Cancer Research There is no effective treatment for patients with poorly differentiated papillary thyroid cancer or anaplastic thyroid cancer (ATC). Anlotinib, a multi-kinase inhibitor, has already shown antitumor effects in various types of carcinoma in a phase I clinical trial. In this study, we aimed to better understand the effect and efficacy of anlotinib against thyroid carcinoma cells in vitro and in vivo. We found that anlotinib inhibits the cell viability of papillary thyroid cancer and ATC cell lines, likely due to abnormal spindle assembly, G2/M arrest, and activation of TP53 upon anlotinib treatment. Moreover, anlotinib suppresses the migration of thyroid cancer cells in vitro and the growth of xenograft thyroid tumors in mice. Our data demonstrate that anlotinib has significant anticancer activity in thyroid cancer, and potentially offers an effective therapeutic strategy for patients of advanced thyroid cancer type. Bioscientifica Ltd 2018-08-21 /pmc/articles/PMC6215907/ /pubmed/30139768 http://dx.doi.org/10.1530/ERC-17-0558 Text en © 2018 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Ruan, Xianhui Shi, Xianle Dong, Qiman Yu, Yang Hou, Xiukun Song, Xinhao Wei, Xi Chen, Lingyi Gao, Ming Antitumor effects of anlotinib in thyroid cancer |
title | Antitumor effects of anlotinib in thyroid cancer |
title_full | Antitumor effects of anlotinib in thyroid cancer |
title_fullStr | Antitumor effects of anlotinib in thyroid cancer |
title_full_unstemmed | Antitumor effects of anlotinib in thyroid cancer |
title_short | Antitumor effects of anlotinib in thyroid cancer |
title_sort | antitumor effects of anlotinib in thyroid cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215907/ https://www.ncbi.nlm.nih.gov/pubmed/30139768 http://dx.doi.org/10.1530/ERC-17-0558 |
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