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Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression
INTRODUCTION: Cerebrovascular disease (CVD) is not currently considered a core pathological feature of Alzheimer's disease (AD), but mounting evidence suggests that concurrent CVD may exacerbate AD progression. The purpose of this study was first to examine the relationship among amyloid, CVD,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215981/ https://www.ncbi.nlm.nih.gov/pubmed/30417071 http://dx.doi.org/10.1016/j.dadm.2018.08.007 |
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author | Lao, Patrick J. Brickman, Adam M. |
author_facet | Lao, Patrick J. Brickman, Adam M. |
author_sort | Lao, Patrick J. |
collection | PubMed |
description | INTRODUCTION: Cerebrovascular disease (CVD) is not currently considered a core pathological feature of Alzheimer's disease (AD), but mounting evidence suggests that concurrent CVD may exacerbate AD progression. The purpose of this study was first to examine the relationship among amyloid, CVD, and neurodegeneration and second to examine the extent to which amyloid and CVD pathology drive subsequent neurodegeneration over time. METHODS: Six hundred eight (224 normal controls, 291 mild cognitive impairment, 93 AD) subjects from the Alzheimer's Disease Neuroimaging Initiative with longitudinal AV45 positron emission tomography imaging and MR imaging were investigated. RESULTS: Amyloid and white matter hyperintensity (WMH) burden increased across clinical diagnosis groups (normal control < mild cognitive impairment < AD). Amyloid pathology and WMH volume were related to lower cortical thickness, while WMH burden was associated with neurodegenerative/atrophic changes over time in key AD-related brain regions. DISCUSSION: CVD and AD may be etiologically independent, but our findings suggest that CVD should be considered explicitly for its effect on AD progression. |
format | Online Article Text |
id | pubmed-6215981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-62159812018-11-09 Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression Lao, Patrick J. Brickman, Adam M. Alzheimers Dement (Amst) Neuroimaging INTRODUCTION: Cerebrovascular disease (CVD) is not currently considered a core pathological feature of Alzheimer's disease (AD), but mounting evidence suggests that concurrent CVD may exacerbate AD progression. The purpose of this study was first to examine the relationship among amyloid, CVD, and neurodegeneration and second to examine the extent to which amyloid and CVD pathology drive subsequent neurodegeneration over time. METHODS: Six hundred eight (224 normal controls, 291 mild cognitive impairment, 93 AD) subjects from the Alzheimer's Disease Neuroimaging Initiative with longitudinal AV45 positron emission tomography imaging and MR imaging were investigated. RESULTS: Amyloid and white matter hyperintensity (WMH) burden increased across clinical diagnosis groups (normal control < mild cognitive impairment < AD). Amyloid pathology and WMH volume were related to lower cortical thickness, while WMH burden was associated with neurodegenerative/atrophic changes over time in key AD-related brain regions. DISCUSSION: CVD and AD may be etiologically independent, but our findings suggest that CVD should be considered explicitly for its effect on AD progression. Elsevier 2018-09-22 /pmc/articles/PMC6215981/ /pubmed/30417071 http://dx.doi.org/10.1016/j.dadm.2018.08.007 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Neuroimaging Lao, Patrick J. Brickman, Adam M. Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression |
title | Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression |
title_full | Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression |
title_fullStr | Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression |
title_full_unstemmed | Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression |
title_short | Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression |
title_sort | multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in alzheimer's disease progression |
topic | Neuroimaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215981/ https://www.ncbi.nlm.nih.gov/pubmed/30417071 http://dx.doi.org/10.1016/j.dadm.2018.08.007 |
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