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Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC

Resistance to tyrosine kinase inhibitor (TKI) therapy is often accompanied by various genetic alterations, and radiation is an important weapon for changing the DNA of tumor cells. In radiotherapy combined with TKI therapy for non-small cell lung cancer (NSCLC), the two treatment strategies affect a...

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Autor principal: Zhuang, Hongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216000/
https://www.ncbi.nlm.nih.gov/pubmed/30405851
http://dx.doi.org/10.7150/jca.26364
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author Zhuang, Hongqing
author_facet Zhuang, Hongqing
author_sort Zhuang, Hongqing
collection PubMed
description Resistance to tyrosine kinase inhibitor (TKI) therapy is often accompanied by various genetic alterations, and radiation is an important weapon for changing the DNA of tumor cells. In radiotherapy combined with TKI therapy for non-small cell lung cancer (NSCLC), the two treatment strategies affect and interact with each other, resulting in complex tumor resistance mechanisms. Accordingly, tumor progression management after radiotherapy combined with TKI therapy should be different from that after TKI therapy alone. However, current clinical practice is entirely based on the resistance mechanisms of simple TKI therapy. Therefore, it is imperative to investigate the impact of radiation on the mechanism of TKI resistance. However, due to the complexity of the resistance mechanisms under the combined effect of both therapies, such studies remain extremely challenging and time-consuming.
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spelling pubmed-62160002018-11-07 Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC Zhuang, Hongqing J Cancer Review Resistance to tyrosine kinase inhibitor (TKI) therapy is often accompanied by various genetic alterations, and radiation is an important weapon for changing the DNA of tumor cells. In radiotherapy combined with TKI therapy for non-small cell lung cancer (NSCLC), the two treatment strategies affect and interact with each other, resulting in complex tumor resistance mechanisms. Accordingly, tumor progression management after radiotherapy combined with TKI therapy should be different from that after TKI therapy alone. However, current clinical practice is entirely based on the resistance mechanisms of simple TKI therapy. Therefore, it is imperative to investigate the impact of radiation on the mechanism of TKI resistance. However, due to the complexity of the resistance mechanisms under the combined effect of both therapies, such studies remain extremely challenging and time-consuming. Ivyspring International Publisher 2018-10-01 /pmc/articles/PMC6216000/ /pubmed/30405851 http://dx.doi.org/10.7150/jca.26364 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zhuang, Hongqing
Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC
title Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC
title_full Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC
title_fullStr Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC
title_full_unstemmed Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC
title_short Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC
title_sort research progress on the impact of radiation on tki resistance mechanisms in nsclc
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216000/
https://www.ncbi.nlm.nih.gov/pubmed/30405851
http://dx.doi.org/10.7150/jca.26364
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