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Oncogenic virus-induced aerobic glycolysis and tumorigenesis
Enhanced glycolysis under normoxic conditions is known as aerobic glycolysis or the Warburg effect and is a hallmark of many tumors. Viral infection may also induce aerobic glycolysis as it is required for replication and survival. Tumor viruses inducing aerobic glycolysis and lactate production dur...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216013/ https://www.ncbi.nlm.nih.gov/pubmed/30405839 http://dx.doi.org/10.7150/jca.27279 |
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author | Yu, Li Chen, Xun Wang, Liantang Chen, Shangwu |
author_facet | Yu, Li Chen, Xun Wang, Liantang Chen, Shangwu |
author_sort | Yu, Li |
collection | PubMed |
description | Enhanced glycolysis under normoxic conditions is known as aerobic glycolysis or the Warburg effect and is a hallmark of many tumors. Viral infection may also induce aerobic glycolysis as it is required for replication and survival. Tumor viruses inducing aerobic glycolysis and lactate production during latent infection suggest a potential role of virus-induced glycolysis in tumorigenesis. Virus or virus-encoded proteins regulate glucose uptake and lactate export, increase the activity of glycolytic enzymes, and modulate glucose metabolic signals. Accumulating evidence suggests that virus-induced glycolysis may facilitate cell growth, transformation, migration, and invasion, but its significance in tumorigenesis remains unclear. We summarize the effects of oncogenic viruses on the metabolic shift to aerobic glycolysis and discuss the possible association of this metabolic reprogramming with tumor development and progression. |
format | Online Article Text |
id | pubmed-6216013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-62160132018-11-07 Oncogenic virus-induced aerobic glycolysis and tumorigenesis Yu, Li Chen, Xun Wang, Liantang Chen, Shangwu J Cancer Review Enhanced glycolysis under normoxic conditions is known as aerobic glycolysis or the Warburg effect and is a hallmark of many tumors. Viral infection may also induce aerobic glycolysis as it is required for replication and survival. Tumor viruses inducing aerobic glycolysis and lactate production during latent infection suggest a potential role of virus-induced glycolysis in tumorigenesis. Virus or virus-encoded proteins regulate glucose uptake and lactate export, increase the activity of glycolytic enzymes, and modulate glucose metabolic signals. Accumulating evidence suggests that virus-induced glycolysis may facilitate cell growth, transformation, migration, and invasion, but its significance in tumorigenesis remains unclear. We summarize the effects of oncogenic viruses on the metabolic shift to aerobic glycolysis and discuss the possible association of this metabolic reprogramming with tumor development and progression. Ivyspring International Publisher 2018-09-08 /pmc/articles/PMC6216013/ /pubmed/30405839 http://dx.doi.org/10.7150/jca.27279 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Yu, Li Chen, Xun Wang, Liantang Chen, Shangwu Oncogenic virus-induced aerobic glycolysis and tumorigenesis |
title | Oncogenic virus-induced aerobic glycolysis and tumorigenesis |
title_full | Oncogenic virus-induced aerobic glycolysis and tumorigenesis |
title_fullStr | Oncogenic virus-induced aerobic glycolysis and tumorigenesis |
title_full_unstemmed | Oncogenic virus-induced aerobic glycolysis and tumorigenesis |
title_short | Oncogenic virus-induced aerobic glycolysis and tumorigenesis |
title_sort | oncogenic virus-induced aerobic glycolysis and tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216013/ https://www.ncbi.nlm.nih.gov/pubmed/30405839 http://dx.doi.org/10.7150/jca.27279 |
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