Role of canonical Hedgehog signaling pathway in liver

Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Lili, Zhang, Zhenya, Zhang, Peng, Yu, Minghua, Yang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216024/
https://www.ncbi.nlm.nih.gov/pubmed/30416378
http://dx.doi.org/10.7150/ijbs.28089
_version_ 1783368259948511232
author Gao, Lili
Zhang, Zhenya
Zhang, Peng
Yu, Minghua
Yang, Tao
author_facet Gao, Lili
Zhang, Zhenya
Zhang, Peng
Yu, Minghua
Yang, Tao
author_sort Gao, Lili
collection PubMed
description Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosis and liver cancers. In this review, we summarize the current knowledge of the role of canonical Hh signaling pathway in adult liver. This help to understand the pathogenesis of liver diseases and find out the new effective targeted therapeutic strategies for liver diseases treatments.
format Online
Article
Text
id pubmed-6216024
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-62160242018-11-09 Role of canonical Hedgehog signaling pathway in liver Gao, Lili Zhang, Zhenya Zhang, Peng Yu, Minghua Yang, Tao Int J Biol Sci Review Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosis and liver cancers. In this review, we summarize the current knowledge of the role of canonical Hh signaling pathway in adult liver. This help to understand the pathogenesis of liver diseases and find out the new effective targeted therapeutic strategies for liver diseases treatments. Ivyspring International Publisher 2018-09-07 /pmc/articles/PMC6216024/ /pubmed/30416378 http://dx.doi.org/10.7150/ijbs.28089 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Gao, Lili
Zhang, Zhenya
Zhang, Peng
Yu, Minghua
Yang, Tao
Role of canonical Hedgehog signaling pathway in liver
title Role of canonical Hedgehog signaling pathway in liver
title_full Role of canonical Hedgehog signaling pathway in liver
title_fullStr Role of canonical Hedgehog signaling pathway in liver
title_full_unstemmed Role of canonical Hedgehog signaling pathway in liver
title_short Role of canonical Hedgehog signaling pathway in liver
title_sort role of canonical hedgehog signaling pathway in liver
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216024/
https://www.ncbi.nlm.nih.gov/pubmed/30416378
http://dx.doi.org/10.7150/ijbs.28089
work_keys_str_mv AT gaolili roleofcanonicalhedgehogsignalingpathwayinliver
AT zhangzhenya roleofcanonicalhedgehogsignalingpathwayinliver
AT zhangpeng roleofcanonicalhedgehogsignalingpathwayinliver
AT yuminghua roleofcanonicalhedgehogsignalingpathwayinliver
AT yangtao roleofcanonicalhedgehogsignalingpathwayinliver

Ejemplares similares