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Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder

Aseptic loosening is the most common complication of joint replacement. Previous studies showed that acrylic bone cement loaded with a commercially-available alendronate powder (APAC) had good promise against wear debris-mediated osteolysis for prevention of aseptic loosening. The purpose of the pre...

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Autores principales: Qu, Guo-Xin, Ying, Zhi-Min, Zhao, Chen-Chen, Yan, Shi-Gui, Cai, Xun-Zi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216052/
https://www.ncbi.nlm.nih.gov/pubmed/30443165
http://dx.doi.org/10.7150/ijms.27759
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author Qu, Guo-Xin
Ying, Zhi-Min
Zhao, Chen-Chen
Yan, Shi-Gui
Cai, Xun-Zi
author_facet Qu, Guo-Xin
Ying, Zhi-Min
Zhao, Chen-Chen
Yan, Shi-Gui
Cai, Xun-Zi
author_sort Qu, Guo-Xin
collection PubMed
description Aseptic loosening is the most common complication of joint replacement. Previous studies showed that acrylic bone cement loaded with a commercially-available alendronate powder (APAC) had good promise against wear debris-mediated osteolysis for prevention of aseptic loosening. The purpose of the present study was to investigate the effect of adding alendronate powder to an acrylic bone cement on quasi-static mechanical properties (namely, compressive strength, compressive modulus, tensile strength, and flexural strength), fatigue life, porosity, and microstructure of the cement. The results showed that adding up to 1 wt./wt.% alendronate powder exerted no detrimental effect on any of the quasi-static mechanical properties. However, the fatigue life of APAC decreased by between ~17% and ~27 % and its porosity increased by between ~ 5-7 times compared with corresponding values for the control cement (no alendronate powder added). Fatigue life was negatively and significantly correlated with porosity. Considering that fatigue life of the cement plays a significant role in joint replacement survival, clinical use of APAC cannot be recommended.
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spelling pubmed-62160522018-11-15 Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder Qu, Guo-Xin Ying, Zhi-Min Zhao, Chen-Chen Yan, Shi-Gui Cai, Xun-Zi Int J Med Sci Research Paper Aseptic loosening is the most common complication of joint replacement. Previous studies showed that acrylic bone cement loaded with a commercially-available alendronate powder (APAC) had good promise against wear debris-mediated osteolysis for prevention of aseptic loosening. The purpose of the present study was to investigate the effect of adding alendronate powder to an acrylic bone cement on quasi-static mechanical properties (namely, compressive strength, compressive modulus, tensile strength, and flexural strength), fatigue life, porosity, and microstructure of the cement. The results showed that adding up to 1 wt./wt.% alendronate powder exerted no detrimental effect on any of the quasi-static mechanical properties. However, the fatigue life of APAC decreased by between ~17% and ~27 % and its porosity increased by between ~ 5-7 times compared with corresponding values for the control cement (no alendronate powder added). Fatigue life was negatively and significantly correlated with porosity. Considering that fatigue life of the cement plays a significant role in joint replacement survival, clinical use of APAC cannot be recommended. Ivyspring International Publisher 2018-09-07 /pmc/articles/PMC6216052/ /pubmed/30443165 http://dx.doi.org/10.7150/ijms.27759 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Qu, Guo-Xin
Ying, Zhi-Min
Zhao, Chen-Chen
Yan, Shi-Gui
Cai, Xun-Zi
Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder
title Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder
title_full Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder
title_fullStr Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder
title_full_unstemmed Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder
title_short Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder
title_sort mechanical properties and porosity of acrylic cement bone loaded with alendronate powder
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216052/
https://www.ncbi.nlm.nih.gov/pubmed/30443165
http://dx.doi.org/10.7150/ijms.27759
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