Comparison of Oxidative Stress Effects on Senescence Patterning of Human Adult and Perinatal Tissue-Derived Stem Cells in Short and Long-term Cultures

Human Mesenchymal Stem Cells (hMSCs) undergo senescence in lifespan. In most clinical trials, hMSCs experience long-term expansion ex vivo to increase cell number prior to transplantation, which unfortunately leads to cell senescence, hampering post-transplant outcomes. Hydrogen peroxide (H(2)O(2))...

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Detalles Bibliográficos
Autores principales: Facchin, Federica, Bianconi, Eva, Romano, Miriam, Impellizzeri, Alessia, Alviano, Francesco, Maioli, Margherita, Canaider, Silvia, Ventura, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216057/
https://www.ncbi.nlm.nih.gov/pubmed/30443170
http://dx.doi.org/10.7150/ijms.27181

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