Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta

The present study aimed to investigate the effects of ethanol extract from Brucea javanicaseed (EEBJS) on the angiogenesis of human umbilical vein endothelial cells (HUVECs) and the possible molecular signal involved. Firstly, a Matrigel-based in vitro angiogenesis assay demonstrated that EEBJS inhi...

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Detalles Bibliográficos
Autores principales: Wang, Xiaotong, Li, Yunyun, Mou, Yan, Yue, Zhen, Zhang, Haiying, Li, Ronggui, Sun, Hongxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216067/
https://www.ncbi.nlm.nih.gov/pubmed/30443173
http://dx.doi.org/10.7150/ijms.28337
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author Wang, Xiaotong
Li, Yunyun
Mou, Yan
Yue, Zhen
Zhang, Haiying
Li, Ronggui
Sun, Hongxia
author_facet Wang, Xiaotong
Li, Yunyun
Mou, Yan
Yue, Zhen
Zhang, Haiying
Li, Ronggui
Sun, Hongxia
author_sort Wang, Xiaotong
collection PubMed
description The present study aimed to investigate the effects of ethanol extract from Brucea javanicaseed (EEBJS) on the angiogenesis of human umbilical vein endothelial cells (HUVECs) and the possible molecular signal involved. Firstly, a Matrigel-based in vitro angiogenesis assay demonstrated that EEBJS inhibited the angiogenesis of HUVECs in a dose-dependent manner. Then by using porcine aortic endothelial cells which stably express human PDGFR-beta, we found that the inhibition of angiogenesis was mediated by PDGFR-beta. Taken together, we conclude that EEBJS inhibited the angiogenesis function of the vascular endothelial cells mediated by PDGFR-beta, and postulate that it might contribute to the therapeutic effects of EEBJS on malignant tumors.
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spelling pubmed-62160672018-11-15 Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta Wang, Xiaotong Li, Yunyun Mou, Yan Yue, Zhen Zhang, Haiying Li, Ronggui Sun, Hongxia Int J Med Sci Research Paper The present study aimed to investigate the effects of ethanol extract from Brucea javanicaseed (EEBJS) on the angiogenesis of human umbilical vein endothelial cells (HUVECs) and the possible molecular signal involved. Firstly, a Matrigel-based in vitro angiogenesis assay demonstrated that EEBJS inhibited the angiogenesis of HUVECs in a dose-dependent manner. Then by using porcine aortic endothelial cells which stably express human PDGFR-beta, we found that the inhibition of angiogenesis was mediated by PDGFR-beta. Taken together, we conclude that EEBJS inhibited the angiogenesis function of the vascular endothelial cells mediated by PDGFR-beta, and postulate that it might contribute to the therapeutic effects of EEBJS on malignant tumors. Ivyspring International Publisher 2018-10-20 /pmc/articles/PMC6216067/ /pubmed/30443173 http://dx.doi.org/10.7150/ijms.28337 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Xiaotong
Li, Yunyun
Mou, Yan
Yue, Zhen
Zhang, Haiying
Li, Ronggui
Sun, Hongxia
Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta
title Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta
title_full Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta
title_fullStr Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta
title_full_unstemmed Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta
title_short Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta
title_sort ethanol extract from brucea javanica seed inhibits angiogenesis mediated by platelet derived growth factor receptor-beta
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216067/
https://www.ncbi.nlm.nih.gov/pubmed/30443173
http://dx.doi.org/10.7150/ijms.28337
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