Mutant MRPS5 affects mitoribosomal accuracy and confers stress‐related behavioral alterations

The 1555 A to G substitution in mitochondrial 12S A‐site rRNA is associated with maternally transmitted deafness of variable penetrance in the absence of otherwise overt disease. Here, we recapitulate the suggested A1555G‐mediated pathomechanism in an experimental model of mitoribosomal mistranslati...

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Detalles Bibliográficos
Autores principales: Akbergenov, Rashid, Duscha, Stefan, Fritz, Ann‐Kristina, Juskeviciene, Reda, Oishi, Naoki, Schmitt, Karen, Shcherbakov, Dimitri, Teo, Youjin, Boukari, Heithem, Freihofer, Pietro, Isnard‐Petit, Patricia, Oettinghaus, Björn, Frank, Stephan, Thiam, Kader, Rehrauer, Hubert, Westhof, Eric, Schacht, Jochen, Eckert, Anne, Wolfer, David, Böttger, Erik C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216279/
https://www.ncbi.nlm.nih.gov/pubmed/30237157
http://dx.doi.org/10.15252/embr.201846193

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