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The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake

Low doses of radiation affect the response of cells to higher doses; this phenomenon is called radio-adaptive response, which leads to increased resistance to subsequent higher doses. We have investigated the adaptive response using 0.37 MBq priming dose of I-131 followed by 296–444 MBq challenging...

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Autores principales: Fazeli, Zahra, Monfared, Ali Shabestani, Zakavi, Seyed Rasoul, Amiri, Mehrangiz, Zabihi, Ebrahim, Borzoueisileh, Sajad, Gholami, Amir, Gorji, Kourosh Ebrahimnejad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216742/
https://www.ncbi.nlm.nih.gov/pubmed/30505225
http://dx.doi.org/10.4103/wjnm.WJNM_83_17
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author Fazeli, Zahra
Monfared, Ali Shabestani
Zakavi, Seyed Rasoul
Amiri, Mehrangiz
Zabihi, Ebrahim
Borzoueisileh, Sajad
Gholami, Amir
Gorji, Kourosh Ebrahimnejad
author_facet Fazeli, Zahra
Monfared, Ali Shabestani
Zakavi, Seyed Rasoul
Amiri, Mehrangiz
Zabihi, Ebrahim
Borzoueisileh, Sajad
Gholami, Amir
Gorji, Kourosh Ebrahimnejad
author_sort Fazeli, Zahra
collection PubMed
description Low doses of radiation affect the response of cells to higher doses; this phenomenon is called radio-adaptive response, which leads to increased resistance to subsequent higher doses. We have investigated the adaptive response using 0.37 MBq priming dose of I-131 followed by 296–444 MBq challenging dose in peripheral human lymphocyte cells. The study was performed on 42 patients with Graves' disease and 29 healthy adult persons as a control group. The patients were divided into two groups. In the first group, patients were referred for radioactive iodine therapy with a specific dose, and iodine was given to them on the day of referral. In the second group, patients were referred for radioactive iodine uptake and radioactive iodine therapy, and iodine uptake was initially performed, then 24 h later, iodine therapy was done. In both groups, 1 month after treatment, blood samples were taken to cytokinesis-block micronucleus (MN) assay. The number of MN in binuclear lymphocyte cells was counted as an end point test. The mean frequency of MN in first, second, and control groups was 75.86 ± 12.68, 71.45 ± 12.56, and 20.06 ± 7.30, respectively. Our results showed that the frequency of total chromosome aberration in both radiation groups was higher than controls. However, in the first group was higher than another group, but their difference was not statistically significant. According to the results, we cannot approve the hypothesis that 0.37 MBq I-131 administration before iodine therapy could induce a radio-adaptive response in lymphocytes of Graves' patients.
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spelling pubmed-62167422018-11-30 The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake Fazeli, Zahra Monfared, Ali Shabestani Zakavi, Seyed Rasoul Amiri, Mehrangiz Zabihi, Ebrahim Borzoueisileh, Sajad Gholami, Amir Gorji, Kourosh Ebrahimnejad World J Nucl Med Original Article Low doses of radiation affect the response of cells to higher doses; this phenomenon is called radio-adaptive response, which leads to increased resistance to subsequent higher doses. We have investigated the adaptive response using 0.37 MBq priming dose of I-131 followed by 296–444 MBq challenging dose in peripheral human lymphocyte cells. The study was performed on 42 patients with Graves' disease and 29 healthy adult persons as a control group. The patients were divided into two groups. In the first group, patients were referred for radioactive iodine therapy with a specific dose, and iodine was given to them on the day of referral. In the second group, patients were referred for radioactive iodine uptake and radioactive iodine therapy, and iodine uptake was initially performed, then 24 h later, iodine therapy was done. In both groups, 1 month after treatment, blood samples were taken to cytokinesis-block micronucleus (MN) assay. The number of MN in binuclear lymphocyte cells was counted as an end point test. The mean frequency of MN in first, second, and control groups was 75.86 ± 12.68, 71.45 ± 12.56, and 20.06 ± 7.30, respectively. Our results showed that the frequency of total chromosome aberration in both radiation groups was higher than controls. However, in the first group was higher than another group, but their difference was not statistically significant. According to the results, we cannot approve the hypothesis that 0.37 MBq I-131 administration before iodine therapy could induce a radio-adaptive response in lymphocytes of Graves' patients. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6216742/ /pubmed/30505225 http://dx.doi.org/10.4103/wjnm.WJNM_83_17 Text en Copyright: © 2018 World Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Fazeli, Zahra
Monfared, Ali Shabestani
Zakavi, Seyed Rasoul
Amiri, Mehrangiz
Zabihi, Ebrahim
Borzoueisileh, Sajad
Gholami, Amir
Gorji, Kourosh Ebrahimnejad
The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
title The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
title_full The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
title_fullStr The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
title_full_unstemmed The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
title_short The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
title_sort assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216742/
https://www.ncbi.nlm.nih.gov/pubmed/30505225
http://dx.doi.org/10.4103/wjnm.WJNM_83_17
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