Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma

In recent reports, we have shown that optimized pretargeted radioimmunotherapy (PRIT) based on molecularly engineered antibody conjugates and (177)Lu-DOTA chelate (DOTA-PRIT) can be used to cure mice bearing human solid tumor xenografts using antitumor antibodies to minimally internalizing membrane...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheal, Sarah M., Xu, Hong, Guo, Hong-fen, Patel, Mitesh, Punzalan, Blesida, Fung, Edward K., Lee, Sang-gyu, Bell, Meghan, Singh, Manisha, Jungbluth, Achim A., Zanzonico, Pat B., Piersigilli, Alessandra, Larson, Steven M., Cheung, Nai-Kong V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217068/
https://www.ncbi.nlm.nih.gov/pubmed/30429889
http://dx.doi.org/10.7150/thno.26585

Ejemplares similares

Ejemplares similares