Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain

The E3 ubiquitin ligase CRL4(COP1/DET1) is active in the absence of ERK signaling, modifying the transcription factors ETV1, ETV4, ETV5, and c-JUN with polyubiquitin that targets them for proteasomal degradation. Here we show that this posttranslational regulatory mechanism is active in neurons, wit...

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Detalles Bibliográficos
Autores principales: Newton, Kim, Dugger, Debra L., Sengupta-Ghosh, Arundhati, Ferrando, Ronald E., Chu, Felix, Tao, Janet, Lam, Wendy, Haller, Susan, Chan, Sara, Sa, Susan, Dunlap, Debra, Eastham-Anderson, Jeffrey, Ngu, Hai, Hung, Jeffrey, French, Dorothy M., Webster, Joshua D., Bolon, Brad, Liu, Jinfeng, Reja, Rohit, Kummerfeld, Sarah, Chen, Ying-Jiun, Modrusan, Zora, Lewcock, Joseph W., Dixit, Vishva M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217379/
https://www.ncbi.nlm.nih.gov/pubmed/30322923
http://dx.doi.org/10.1073/pnas.1805033115

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