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Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock

Mammalian physiology resonates with the daily changes in the external environment, allowing processes such as rest–activity cycles, metabolism, and body temperature to synchronize with daily changes in the surroundings. Studies have identified the molecular underpinnings of robust oscillations in ge...

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Detalles Bibliográficos
Autores principales: Gachon, Frédéric, Yeung, Jake, Naef, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217737/
https://www.ncbi.nlm.nih.gov/pubmed/30385518
http://dx.doi.org/10.1101/gad.320911.118
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author Gachon, Frédéric
Yeung, Jake
Naef, Felix
author_facet Gachon, Frédéric
Yeung, Jake
Naef, Felix
author_sort Gachon, Frédéric
collection PubMed
description Mammalian physiology resonates with the daily changes in the external environment, allowing processes such as rest–activity cycles, metabolism, and body temperature to synchronize with daily changes in the surroundings. Studies have identified the molecular underpinnings of robust oscillations in gene expression occurring over the 24-h day, but how acute or chronic perturbations modulate gene expression rhythms, physiology, and behavior is still relatively unknown. In this issue of Genes & Development, Hong and colleagues (pp. 1367–1379) studied how acute and chronic inflammation interacts with the circadian clock. They found that NF-κB signaling can modify chromatin states and modulate expression of genes in the core clock network as well as circadian locomotor behavior. Interestingly, a high-fat diet (HFD) fed to mice also triggers this inflammation pathway, suggesting that cross-regulatory circuits link inflammation, HFD, and the circadian clock.
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spelling pubmed-62177372019-05-01 Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock Gachon, Frédéric Yeung, Jake Naef, Felix Genes Dev Outlook Mammalian physiology resonates with the daily changes in the external environment, allowing processes such as rest–activity cycles, metabolism, and body temperature to synchronize with daily changes in the surroundings. Studies have identified the molecular underpinnings of robust oscillations in gene expression occurring over the 24-h day, but how acute or chronic perturbations modulate gene expression rhythms, physiology, and behavior is still relatively unknown. In this issue of Genes & Development, Hong and colleagues (pp. 1367–1379) studied how acute and chronic inflammation interacts with the circadian clock. They found that NF-κB signaling can modify chromatin states and modulate expression of genes in the core clock network as well as circadian locomotor behavior. Interestingly, a high-fat diet (HFD) fed to mice also triggers this inflammation pathway, suggesting that cross-regulatory circuits link inflammation, HFD, and the circadian clock. Cold Spring Harbor Laboratory Press 2018-11-01 /pmc/articles/PMC6217737/ /pubmed/30385518 http://dx.doi.org/10.1101/gad.320911.118 Text en © 2018 Gachon et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Gachon, Frédéric
Yeung, Jake
Naef, Felix
Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
title Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
title_full Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
title_fullStr Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
title_full_unstemmed Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
title_short Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
title_sort cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217737/
https://www.ncbi.nlm.nih.gov/pubmed/30385518
http://dx.doi.org/10.1101/gad.320911.118
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