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Myokines as Possible Therapeutic Targets in Cancer Cachexia
Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient's quality of life, and i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217752/ https://www.ncbi.nlm.nih.gov/pubmed/30426026 http://dx.doi.org/10.1155/2018/8260742 |
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author | Manole, Emilia Ceafalan, Laura C. Popescu, Bogdan O. Dumitru, Carmen Bastian, Alexandra E. |
author_facet | Manole, Emilia Ceafalan, Laura C. Popescu, Bogdan O. Dumitru, Carmen Bastian, Alexandra E. |
author_sort | Manole, Emilia |
collection | PubMed |
description | Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient's quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15. |
format | Online Article Text |
id | pubmed-6217752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-62177522018-11-13 Myokines as Possible Therapeutic Targets in Cancer Cachexia Manole, Emilia Ceafalan, Laura C. Popescu, Bogdan O. Dumitru, Carmen Bastian, Alexandra E. J Immunol Res Review Article Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient's quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15. Hindawi 2018-10-22 /pmc/articles/PMC6217752/ /pubmed/30426026 http://dx.doi.org/10.1155/2018/8260742 Text en Copyright © 2018 Emilia Manole et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Manole, Emilia Ceafalan, Laura C. Popescu, Bogdan O. Dumitru, Carmen Bastian, Alexandra E. Myokines as Possible Therapeutic Targets in Cancer Cachexia |
title | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
title_full | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
title_fullStr | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
title_full_unstemmed | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
title_short | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
title_sort | myokines as possible therapeutic targets in cancer cachexia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217752/ https://www.ncbi.nlm.nih.gov/pubmed/30426026 http://dx.doi.org/10.1155/2018/8260742 |
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