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Myokines as Possible Therapeutic Targets in Cancer Cachexia

Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient's quality of life, and i...

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Autores principales: Manole, Emilia, Ceafalan, Laura C., Popescu, Bogdan O., Dumitru, Carmen, Bastian, Alexandra E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217752/
https://www.ncbi.nlm.nih.gov/pubmed/30426026
http://dx.doi.org/10.1155/2018/8260742
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author Manole, Emilia
Ceafalan, Laura C.
Popescu, Bogdan O.
Dumitru, Carmen
Bastian, Alexandra E.
author_facet Manole, Emilia
Ceafalan, Laura C.
Popescu, Bogdan O.
Dumitru, Carmen
Bastian, Alexandra E.
author_sort Manole, Emilia
collection PubMed
description Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient's quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15.
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spelling pubmed-62177522018-11-13 Myokines as Possible Therapeutic Targets in Cancer Cachexia Manole, Emilia Ceafalan, Laura C. Popescu, Bogdan O. Dumitru, Carmen Bastian, Alexandra E. J Immunol Res Review Article Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient's quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15. Hindawi 2018-10-22 /pmc/articles/PMC6217752/ /pubmed/30426026 http://dx.doi.org/10.1155/2018/8260742 Text en Copyright © 2018 Emilia Manole et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Manole, Emilia
Ceafalan, Laura C.
Popescu, Bogdan O.
Dumitru, Carmen
Bastian, Alexandra E.
Myokines as Possible Therapeutic Targets in Cancer Cachexia
title Myokines as Possible Therapeutic Targets in Cancer Cachexia
title_full Myokines as Possible Therapeutic Targets in Cancer Cachexia
title_fullStr Myokines as Possible Therapeutic Targets in Cancer Cachexia
title_full_unstemmed Myokines as Possible Therapeutic Targets in Cancer Cachexia
title_short Myokines as Possible Therapeutic Targets in Cancer Cachexia
title_sort myokines as possible therapeutic targets in cancer cachexia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217752/
https://www.ncbi.nlm.nih.gov/pubmed/30426026
http://dx.doi.org/10.1155/2018/8260742
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