Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient

Liver involvement is a known feature of secondary syphilis. The prevalence of hepatitis in secondary syphilis ranges broadly from 1 to 50%. We report a case of a 37-year-old man with type 1 diabetes mellitus and sickle cell trait presenting with jaundice and acute liver cholestasis. Abdominal ultras...

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Autores principales: Hussain, Nazneen, Igbinedion, Samuel O., Diaz, Richie, Alexander, J. S., Boktor, Moheb, Knowles, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217883/
https://www.ncbi.nlm.nih.gov/pubmed/30425865
http://dx.doi.org/10.1155/2018/8645068
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author Hussain, Nazneen
Igbinedion, Samuel O.
Diaz, Richie
Alexander, J. S.
Boktor, Moheb
Knowles, Kurt
author_facet Hussain, Nazneen
Igbinedion, Samuel O.
Diaz, Richie
Alexander, J. S.
Boktor, Moheb
Knowles, Kurt
author_sort Hussain, Nazneen
collection PubMed
description Liver involvement is a known feature of secondary syphilis. The prevalence of hepatitis in secondary syphilis ranges broadly from 1 to 50%. We report a case of a 37-year-old man with type 1 diabetes mellitus and sickle cell trait presenting with jaundice and acute liver cholestasis. Abdominal ultrasound revealed mild hepatic fatty infiltration. RPR and Treponema pallidum IgG results were positive with a reflex titer of 1:64. Liver biopsy revealed chronic hepatitis with normal hepatic architecture, Kupffer cell hyperplasia, hepatic cholestasis, and ductal proliferation suggestive of syphilitic hepatitis.
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spelling pubmed-62178832018-11-13 Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient Hussain, Nazneen Igbinedion, Samuel O. Diaz, Richie Alexander, J. S. Boktor, Moheb Knowles, Kurt Case Reports Hepatol Case Report Liver involvement is a known feature of secondary syphilis. The prevalence of hepatitis in secondary syphilis ranges broadly from 1 to 50%. We report a case of a 37-year-old man with type 1 diabetes mellitus and sickle cell trait presenting with jaundice and acute liver cholestasis. Abdominal ultrasound revealed mild hepatic fatty infiltration. RPR and Treponema pallidum IgG results were positive with a reflex titer of 1:64. Liver biopsy revealed chronic hepatitis with normal hepatic architecture, Kupffer cell hyperplasia, hepatic cholestasis, and ductal proliferation suggestive of syphilitic hepatitis. Hindawi 2018-10-22 /pmc/articles/PMC6217883/ /pubmed/30425865 http://dx.doi.org/10.1155/2018/8645068 Text en Copyright © 2018 Nazneen Hussain et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hussain, Nazneen
Igbinedion, Samuel O.
Diaz, Richie
Alexander, J. S.
Boktor, Moheb
Knowles, Kurt
Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient
title Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient
title_full Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient
title_fullStr Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient
title_full_unstemmed Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient
title_short Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient
title_sort liver cholestasis secondary to syphilis in an immunocompetent patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217883/
https://www.ncbi.nlm.nih.gov/pubmed/30425865
http://dx.doi.org/10.1155/2018/8645068
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