Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response

The skin is in daily contact with environmental pollutants, but the long-term effects of such exposure remain underinvestigated. Many of these toxins bind and activate the pregnane X receptor (PXR), a ligand-activated transcription factor that regulates genes central to xenobiotic metabolism. The ob...

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Detalles Bibliográficos
Autores principales: Elentner, Andreas, Schmuth, Matthias, Yannoutsos, Nikolaos, Eichmann, Thomas O., Gruber, Robert, Radner, Franz P.W., Hermann, Martin, Del Frari, Barbara, Dubrac, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217923/
https://www.ncbi.nlm.nih.gov/pubmed/28927887
http://dx.doi.org/10.1016/j.jid.2017.07.846

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