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Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias
OBJECTIVES: Idiopathic interstitial pneumonia (IIP) and connective tissue disease -associated interstitial pneumonia (CTD-IP) are the two most common types of interstitial pneumonia. IIP and CTD-IP share common histological features, yet their clinical management is different. Separation of the two...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218032/ https://www.ncbi.nlm.nih.gov/pubmed/30395623 http://dx.doi.org/10.1371/journal.pone.0206186 |
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author | Ozasa, Mutsumi Ichikawa, Hiromi Sato, Shuntaro Tanaka, Tomonori Johkoh, Takeshi Kataoka, Kensuke Yamano, Yasuhiko Kondoh, Yasuhiro Nakamura, Hideki Kawakami, Atsushi Bychkov, Andrey Taniguchi, Hiroyuki Fukuoka, Junya |
author_facet | Ozasa, Mutsumi Ichikawa, Hiromi Sato, Shuntaro Tanaka, Tomonori Johkoh, Takeshi Kataoka, Kensuke Yamano, Yasuhiko Kondoh, Yasuhiro Nakamura, Hideki Kawakami, Atsushi Bychkov, Andrey Taniguchi, Hiroyuki Fukuoka, Junya |
author_sort | Ozasa, Mutsumi |
collection | PubMed |
description | OBJECTIVES: Idiopathic interstitial pneumonia (IIP) and connective tissue disease -associated interstitial pneumonia (CTD-IP) are the two most common types of interstitial pneumonia. IIP and CTD-IP share common histological features, yet their clinical management is different. Separation of the two conditions based solely on histology can be challenging, and there are no established criteria. MATERIALS AND METHODS: We selected 105 consecutive cases of IIP (79 usual interstitial pneumonia and 26 non-specific interstitial pneumonia) and 49 cases of CTD-IP for derivation and 32 cases of IIP and 10 cases of CTD-IP for validation. Fourteen histological parameters were evaluated independently by two pathologists for derivation group and graded into 0 to 3. The association between the score for each marker and a diagnosis of CTD was investigated using Fisher’s exact test and stepwise logistic regression analysis. A formula for calculating the probability of IIP and CTD-IP was constructed by the markers identified in the regression test with coefficients for each finding. The formula was confirmed using validation case group. RESULTS: Stepwise logistic regression analysis showed that plasmacytosis, lymphoid follicle with germinal center, and airspace fibrin were suggestive of CTD-IP and that fibroblastic foci, smooth muscle hyperplasia, cellular IP, dense perivascular collagen, and fat metaplasia were suggestive of IIP. The formula used to calculate the probabilities based on estimated values for each finding was created, and user-friendly web based app was composed at www.ctdip.com. On the validation study, 30 out of 32 IIP and eight out of 10 CTD-IPs were distinguished correctly by the app (Specificity: 93%, Sensitivity: 80%). CONCLUSIONS: We identified histological markers and derived a practical formula and user-friendly app to distinguish CTD-IPs from IIP. |
format | Online Article Text |
id | pubmed-6218032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62180322018-11-19 Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias Ozasa, Mutsumi Ichikawa, Hiromi Sato, Shuntaro Tanaka, Tomonori Johkoh, Takeshi Kataoka, Kensuke Yamano, Yasuhiko Kondoh, Yasuhiro Nakamura, Hideki Kawakami, Atsushi Bychkov, Andrey Taniguchi, Hiroyuki Fukuoka, Junya PLoS One Research Article OBJECTIVES: Idiopathic interstitial pneumonia (IIP) and connective tissue disease -associated interstitial pneumonia (CTD-IP) are the two most common types of interstitial pneumonia. IIP and CTD-IP share common histological features, yet their clinical management is different. Separation of the two conditions based solely on histology can be challenging, and there are no established criteria. MATERIALS AND METHODS: We selected 105 consecutive cases of IIP (79 usual interstitial pneumonia and 26 non-specific interstitial pneumonia) and 49 cases of CTD-IP for derivation and 32 cases of IIP and 10 cases of CTD-IP for validation. Fourteen histological parameters were evaluated independently by two pathologists for derivation group and graded into 0 to 3. The association between the score for each marker and a diagnosis of CTD was investigated using Fisher’s exact test and stepwise logistic regression analysis. A formula for calculating the probability of IIP and CTD-IP was constructed by the markers identified in the regression test with coefficients for each finding. The formula was confirmed using validation case group. RESULTS: Stepwise logistic regression analysis showed that plasmacytosis, lymphoid follicle with germinal center, and airspace fibrin were suggestive of CTD-IP and that fibroblastic foci, smooth muscle hyperplasia, cellular IP, dense perivascular collagen, and fat metaplasia were suggestive of IIP. The formula used to calculate the probabilities based on estimated values for each finding was created, and user-friendly web based app was composed at www.ctdip.com. On the validation study, 30 out of 32 IIP and eight out of 10 CTD-IPs were distinguished correctly by the app (Specificity: 93%, Sensitivity: 80%). CONCLUSIONS: We identified histological markers and derived a practical formula and user-friendly app to distinguish CTD-IPs from IIP. Public Library of Science 2018-11-05 /pmc/articles/PMC6218032/ /pubmed/30395623 http://dx.doi.org/10.1371/journal.pone.0206186 Text en © 2018 Ozasa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ozasa, Mutsumi Ichikawa, Hiromi Sato, Shuntaro Tanaka, Tomonori Johkoh, Takeshi Kataoka, Kensuke Yamano, Yasuhiko Kondoh, Yasuhiro Nakamura, Hideki Kawakami, Atsushi Bychkov, Andrey Taniguchi, Hiroyuki Fukuoka, Junya Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias |
title | Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias |
title_full | Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias |
title_fullStr | Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias |
title_full_unstemmed | Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias |
title_short | Proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias |
title_sort | proposed method of histological separation between connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonias |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218032/ https://www.ncbi.nlm.nih.gov/pubmed/30395623 http://dx.doi.org/10.1371/journal.pone.0206186 |
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