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In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease

Diffusible amyloid-β (Aβ) oligomers are currently presumed to be the most cytotoxic Aβ assembly and held responsible to trigger the pathogenesis of Alzheimer’s disease (AD). Thus, Aβ oligomers are a prominent target in AD drug development. Previously, we reported on our solely D-enantiomeric peptide...

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Detalles Bibliográficos
Autores principales:	Schartmann, Elena, Schemmert, Sarah, Niemietz, Nicole, Honold, Dominik, Ziehm, Tamar, Tusche, Markus, Elfgen, Anne, Gering, Ian, Brener, Oleksandr, Shah, Nadim Joni, Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter, Willuweit, Antje
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218115/ https://www.ncbi.nlm.nih.gov/pubmed/29966196 http://dx.doi.org/10.3233/JAD-180165

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