Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study

We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from o...

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Detalles Bibliográficos
Autores principales: Raunio, Anna, Myllykangas, Liisa, Kero, Mia, Polvikoski, Tuomo, Paetau, Anders, Oinas, Minna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218117/
https://www.ncbi.nlm.nih.gov/pubmed/28482633
http://dx.doi.org/10.3233/JAD-170104
Descripción
Sumario:We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. The amygdala LRP was present in one third (33%) of subjects. Only 5% of pure AD subjects, but 85% of pure DLB subjects had LRP in the amygdala. The amygdala LRP was associated with dementia; however, the association was dependent on LRP on other brain regions, and thus was not an independent risk factor. The amygdala-predominant category was a rare (4%) and heterogeneous group.

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