Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study

We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from o...

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Autores principales: Raunio, Anna, Myllykangas, Liisa, Kero, Mia, Polvikoski, Tuomo, Paetau, Anders, Oinas, Minna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218117/
https://www.ncbi.nlm.nih.gov/pubmed/28482633
http://dx.doi.org/10.3233/JAD-170104
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author Raunio, Anna
Myllykangas, Liisa
Kero, Mia
Polvikoski, Tuomo
Paetau, Anders
Oinas, Minna
author_facet Raunio, Anna
Myllykangas, Liisa
Kero, Mia
Polvikoski, Tuomo
Paetau, Anders
Oinas, Minna
author_sort Raunio, Anna
collection PubMed
description We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. The amygdala LRP was present in one third (33%) of subjects. Only 5% of pure AD subjects, but 85% of pure DLB subjects had LRP in the amygdala. The amygdala LRP was associated with dementia; however, the association was dependent on LRP on other brain regions, and thus was not an independent risk factor. The amygdala-predominant category was a rare (4%) and heterogeneous group.
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spelling pubmed-62181172018-11-07 Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study Raunio, Anna Myllykangas, Liisa Kero, Mia Polvikoski, Tuomo Paetau, Anders Oinas, Minna J Alzheimers Dis Short Communication We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. The amygdala LRP was present in one third (33%) of subjects. Only 5% of pure AD subjects, but 85% of pure DLB subjects had LRP in the amygdala. The amygdala LRP was associated with dementia; however, the association was dependent on LRP on other brain regions, and thus was not an independent risk factor. The amygdala-predominant category was a rare (4%) and heterogeneous group. IOS Press 2017-06-05 /pmc/articles/PMC6218117/ /pubmed/28482633 http://dx.doi.org/10.3233/JAD-170104 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Raunio, Anna
Myllykangas, Liisa
Kero, Mia
Polvikoski, Tuomo
Paetau, Anders
Oinas, Minna
Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
title Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
title_full Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
title_fullStr Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
title_full_unstemmed Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
title_short Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
title_sort amygdala α-synuclein pathology in the population-based vantaa 85+ study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218117/
https://www.ncbi.nlm.nih.gov/pubmed/28482633
http://dx.doi.org/10.3233/JAD-170104
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