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Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice

Commonly used Alzheimer’s disease mouse models are based on the ectopic overexpression of the human amyloid precursor protein (APP) gene, together with a mutant presenilin gene. Surprisingly, humanized APP knock-in mouse models carrying a single APP Swedish mutation (App(NL)), failed to develop amyl...

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Detalles Bibliográficos
Autores principales:	Salas, Isabel H., Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Saido, Takaomi C., Dotti, Carlos G., De Strooper, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218137/ https://www.ncbi.nlm.nih.gov/pubmed/30320577 http://dx.doi.org/10.3233/JAD-180410

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