IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

Interferon α (IFNα) is a prompt and efficient orchestrator of host defense against nucleic acids but upon chronicity becomes a potent mediator of autoimmunity. Sustained IFNα signaling is linked to pathogenesis of systemic lupus erythematosus (SLE), an incurable autoimmune disease characterized by a...

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Detalles Bibliográficos
Autores principales: Gkirtzimanaki, Katerina, Kabrani, Eleni, Nikoleri, Dimitra, Polyzos, Alexander, Blanas, Athanasios, Sidiropoulos, Prodromos, Makrigiannakis, Antonis, Bertsias, George, Boumpas, Dimitrios T., Verginis, Panayotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218203/
https://www.ncbi.nlm.nih.gov/pubmed/30355498
http://dx.doi.org/10.1016/j.celrep.2018.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218203/
https://www.ncbi.nlm.nih.gov/pubmed/30355498
http://dx.doi.org/10.1016/j.celrep.2018.09.001

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