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Somatostatin receptors as a new active targeting sites for nanoparticles

The delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with subsequent drugs internalization. Hence, this type...

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Autores principales: Abdellatif, Ahmed A.H., Aldalaen, Sa'ed M., Faisal, Waleed, Tawfeek, Hesham M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218373/
https://www.ncbi.nlm.nih.gov/pubmed/30416362
http://dx.doi.org/10.1016/j.jsps.2018.05.014
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author Abdellatif, Ahmed A.H.
Aldalaen, Sa'ed M.
Faisal, Waleed
Tawfeek, Hesham M.
author_facet Abdellatif, Ahmed A.H.
Aldalaen, Sa'ed M.
Faisal, Waleed
Tawfeek, Hesham M.
author_sort Abdellatif, Ahmed A.H.
collection PubMed
description The delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with subsequent drugs internalization. Hence, this type of interaction would diminish side effects and enhance drug delivery efficacy to the target site. Somatostatin receptors (SSTRs) are one type of G protein-coupled receptors, which could be active targeted for various purposes. There are five SSTRs types (SSTR1-5) which are localized at various organs in the body and spread into different tissues. SSTRs could be considered as a promising target to various nanoparticles which is facilitated when nanoparticles are modified through specific ligand or coating to allow better binding. This review discusses the exploration of SSTRs for active targeting of nanoparticles with certain emphasize on their interaction at the cellular level.
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spelling pubmed-62183732018-11-09 Somatostatin receptors as a new active targeting sites for nanoparticles Abdellatif, Ahmed A.H. Aldalaen, Sa'ed M. Faisal, Waleed Tawfeek, Hesham M. Saudi Pharm J Article The delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with subsequent drugs internalization. Hence, this type of interaction would diminish side effects and enhance drug delivery efficacy to the target site. Somatostatin receptors (SSTRs) are one type of G protein-coupled receptors, which could be active targeted for various purposes. There are five SSTRs types (SSTR1-5) which are localized at various organs in the body and spread into different tissues. SSTRs could be considered as a promising target to various nanoparticles which is facilitated when nanoparticles are modified through specific ligand or coating to allow better binding. This review discusses the exploration of SSTRs for active targeting of nanoparticles with certain emphasize on their interaction at the cellular level. Elsevier 2018-11 2018-05-31 /pmc/articles/PMC6218373/ /pubmed/30416362 http://dx.doi.org/10.1016/j.jsps.2018.05.014 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Abdellatif, Ahmed A.H.
Aldalaen, Sa'ed M.
Faisal, Waleed
Tawfeek, Hesham M.
Somatostatin receptors as a new active targeting sites for nanoparticles
title Somatostatin receptors as a new active targeting sites for nanoparticles
title_full Somatostatin receptors as a new active targeting sites for nanoparticles
title_fullStr Somatostatin receptors as a new active targeting sites for nanoparticles
title_full_unstemmed Somatostatin receptors as a new active targeting sites for nanoparticles
title_short Somatostatin receptors as a new active targeting sites for nanoparticles
title_sort somatostatin receptors as a new active targeting sites for nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218373/
https://www.ncbi.nlm.nih.gov/pubmed/30416362
http://dx.doi.org/10.1016/j.jsps.2018.05.014
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