Exploring the Impact of Single-Nucleotide Polymorphisms on Translation

Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mut...

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Detalles Bibliográficos
Autores principales: Robert, Francis, Pelletier, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218417/
https://www.ncbi.nlm.nih.gov/pubmed/30425729
http://dx.doi.org/10.3389/fgene.2018.00507
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author Robert, Francis
Pelletier, Jerry
author_facet Robert, Francis
Pelletier, Jerry
author_sort Robert, Francis
collection PubMed
description Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mutations on gene expression is still in its infancy. Here, we provide key examples to help understand how mutations present in genes can affect translational output.
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spelling pubmed-62184172018-11-13 Exploring the Impact of Single-Nucleotide Polymorphisms on Translation Robert, Francis Pelletier, Jerry Front Genet Genetics Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mutations on gene expression is still in its infancy. Here, we provide key examples to help understand how mutations present in genes can affect translational output. Frontiers Media S.A. 2018-10-30 /pmc/articles/PMC6218417/ /pubmed/30425729 http://dx.doi.org/10.3389/fgene.2018.00507 Text en Copyright © 2018 Robert and Pelletier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Robert, Francis
Pelletier, Jerry
Exploring the Impact of Single-Nucleotide Polymorphisms on Translation
title Exploring the Impact of Single-Nucleotide Polymorphisms on Translation
title_full Exploring the Impact of Single-Nucleotide Polymorphisms on Translation
title_fullStr Exploring the Impact of Single-Nucleotide Polymorphisms on Translation
title_full_unstemmed Exploring the Impact of Single-Nucleotide Polymorphisms on Translation
title_short Exploring the Impact of Single-Nucleotide Polymorphisms on Translation
title_sort exploring the impact of single-nucleotide polymorphisms on translation
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218417/
https://www.ncbi.nlm.nih.gov/pubmed/30425729
http://dx.doi.org/10.3389/fgene.2018.00507
work_keys_str_mv AT robertfrancis exploringtheimpactofsinglenucleotidepolymorphismsontranslation
AT pelletierjerry exploringtheimpactofsinglenucleotidepolymorphismsontranslation

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