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Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair

Resistance to genotoxic therapies is a primary cause of treatment failure and tumor recurrence. The underlying mechanisms that activate the DNA damage response (DDR) and allow cancer cells to escape the lethal effects of genotoxic therapies remain unclear. Here, we uncover an unexpected mechanism th...

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Detalles Bibliográficos
Autores principales:	Sizemore, Steven T., Zhang, Manchao, Cho, Ju Hwan, Sizemore, Gina M., Hurwitz, Brian, Kaur, Balveen, Lehman, Norman L., Ostrowski, Michael C., Robe, Pierre A., Miao, Weili, Wang, Yinsheng, Chakravarti, Arnab, Xia, Fen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218445/ https://www.ncbi.nlm.nih.gov/pubmed/30297868 http://dx.doi.org/10.1038/s41422-018-0086-7

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