Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells

Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells from diabetic (db/db) mouse kidneys, demethylation of Tgfb...

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Detalles Bibliográficos
Autores principales: Oba, Shigeyoshi, Ayuzawa, Nobuhiro, Nishimoto, Mitsuhiro, Kawarazaki, Wakako, Ueda, Kohei, Hirohama, Daigoro, Kawakami-Mori, Fumiko, Shimosawa, Tatsuo, Marumo, Takeshi, Fujita, Toshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218490/
https://www.ncbi.nlm.nih.gov/pubmed/30397232
http://dx.doi.org/10.1038/s41598-018-34612-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218490/
https://www.ncbi.nlm.nih.gov/pubmed/30397232
http://dx.doi.org/10.1038/s41598-018-34612-3

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