Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism

Previous neuroimaging studies of autism spectrum disorder (ASD) have focused on subjects with IQ > 70 or ASD without considering IQ levels. It remains unclear whether differences in brain anatomy in this population are associated with variations in clinical phenotype. In this study, 19 children w...

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Autores principales: Cai, Jia, Hu, Xiao, Guo, Kuifang, Yang, Pingyuan, Situ, Mingjing, Huang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218606/
https://www.ncbi.nlm.nih.gov/pubmed/30425664
http://dx.doi.org/10.3389/fpsyt.2018.00542
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author Cai, Jia
Hu, Xiao
Guo, Kuifang
Yang, Pingyuan
Situ, Mingjing
Huang, Yi
author_facet Cai, Jia
Hu, Xiao
Guo, Kuifang
Yang, Pingyuan
Situ, Mingjing
Huang, Yi
author_sort Cai, Jia
collection PubMed
description Previous neuroimaging studies of autism spectrum disorder (ASD) have focused on subjects with IQ > 70 or ASD without considering IQ levels. It remains unclear whether differences in brain anatomy in this population are associated with variations in clinical phenotype. In this study, 19 children with low functioning autism (LFA) and 19 children with high functioning autism (HFA) were compared with 27 healthy controls (HC). We found increased gray matter volume (GMV) in the left inferior temporal gyrus in subjects with both HFA and LFA and increased GMV of left middle temporal gyrus BA21 was found only in the LFA group. A significant negative correlation was found between the left inferior temporal gyrus (LITG) and the score of repetitive behavior in the HFA group.
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spelling pubmed-62186062018-11-13 Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism Cai, Jia Hu, Xiao Guo, Kuifang Yang, Pingyuan Situ, Mingjing Huang, Yi Front Psychiatry Psychiatry Previous neuroimaging studies of autism spectrum disorder (ASD) have focused on subjects with IQ > 70 or ASD without considering IQ levels. It remains unclear whether differences in brain anatomy in this population are associated with variations in clinical phenotype. In this study, 19 children with low functioning autism (LFA) and 19 children with high functioning autism (HFA) were compared with 27 healthy controls (HC). We found increased gray matter volume (GMV) in the left inferior temporal gyrus in subjects with both HFA and LFA and increased GMV of left middle temporal gyrus BA21 was found only in the LFA group. A significant negative correlation was found between the left inferior temporal gyrus (LITG) and the score of repetitive behavior in the HFA group. Frontiers Media S.A. 2018-10-30 /pmc/articles/PMC6218606/ /pubmed/30425664 http://dx.doi.org/10.3389/fpsyt.2018.00542 Text en Copyright © 2018 Cai, Hu, Guo, Yang, Situ and Huang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Cai, Jia
Hu, Xiao
Guo, Kuifang
Yang, Pingyuan
Situ, Mingjing
Huang, Yi
Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism
title Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism
title_full Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism
title_fullStr Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism
title_full_unstemmed Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism
title_short Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism
title_sort increased left inferior temporal gyrus was found in both low function autism and high function autism
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218606/
https://www.ncbi.nlm.nih.gov/pubmed/30425664
http://dx.doi.org/10.3389/fpsyt.2018.00542
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