GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation

Recombinant human growth differentiation factor 15 (rhGDF15) affects dendritic cell (DC) maturation. However, whether GDF15 is expressed in DCs and its roles and signaling in DCs remain largely unknown. It is unclear whether GDF15-DCs can induce immune tolerance in heart transplantation (HT). This s...

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Detalles Bibliográficos
Autores principales: Zhang, Yixin, Zhang, Guangfeng, Liu, Yanling, Chen, Renqi, Zhao, Duo, McAlister, Vivian, Mele, Tina, Liu, Kexiang, Zheng, Xiufen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218625/
https://www.ncbi.nlm.nih.gov/pubmed/30425709
http://dx.doi.org/10.3389/fimmu.2018.02407

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