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The solid-state conformation of the topical antifungal agent O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
Tolnaftate, a classic antifungal compound, has been found to crystallize from 1:1 (v/v) acetone–water as large flat colorless needles in the centrosymmetric monoclinic space group P2(1)/c. These crystals contain a 50:50 mixture of the (+ap,−sp,+ac,−ac) and (−ap,+sp,−ac,+ac) conformers. The bond len...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218884/ https://www.ncbi.nlm.nih.gov/pubmed/30398206 http://dx.doi.org/10.1107/S2053229618013591 |