Crystal structure and metabolic activity of 4-(thien-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexa­hydro­quinoline-3-carb­oxy­lic acid eth­oxy­carbonyl­phenyl­methyl­ester

In the title compound, C(25)H(25)NO(5)S, which exhibits metabolism-regulating activity, the 1,4-di­hydro­pyridine ring adopts a flattened boat conformation while the cyclo­hexenone ring is in an envelope conformation. Mol­ecules in the crystal are assembled into C(6) chains along the a-axis directio...

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Detalles Bibliográficos
Autores principales: Mishnev, Anatoly, Bisenieks, Egils, Mandrika, Ilona, Petrovska, Ramona, Kalme, Zenta, Bruvere, Imanta, Duburs, Gunars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218899/
https://www.ncbi.nlm.nih.gov/pubmed/30443384
http://dx.doi.org/10.1107/S2056989018014251
Descripción
Sumario:In the title compound, C(25)H(25)NO(5)S, which exhibits metabolism-regulating activity, the 1,4-di­hydro­pyridine ring adopts a flattened boat conformation while the cyclo­hexenone ring is in an envelope conformation. Mol­ecules in the crystal are assembled into C(6) chains along the a-axis direction via N—H⋯O hydrogen bonds. The thienyl fragment is disordered over two sets of sites in a 0.7220 (19):0.2780 (19) ratio.

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