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The methanol sesquisolvate of sodium naproxen

The asymmetric unit of the methanol solvate of sodium naproxen, systematic name: sodium (2S)-2-(6-meth­oxy­naphthalen-2-yl)propano­ate methanol sesquisolvate, Na(+)·C(14)H(13)O(3) (−)·1.5CH(3)OH, comprises two formula units of the mol­ecular salt and three methanol mol­ecules. One of the sodium cati...

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Detalles Bibliográficos
Autores principales: Kriegner, Helene, Weil, Matthias, Jones, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218915/
https://www.ncbi.nlm.nih.gov/pubmed/30443394
http://dx.doi.org/10.1107/S2056989018014652
Descripción
Sumario:The asymmetric unit of the methanol solvate of sodium naproxen, systematic name: sodium (2S)-2-(6-meth­oxy­naphthalen-2-yl)propano­ate methanol sesquisolvate, Na(+)·C(14)H(13)O(3) (−)·1.5CH(3)OH, comprises two formula units of the mol­ecular salt and three methanol mol­ecules. One of the sodium cations exhibits a coordination number of six and is bonded to three carboxyl­ate O atoms and three methanol OH groups whereas the second sodium cation has a coordination number of seven, defined by five carboxyl­ate O atoms and two methanol OH groups. Both coordination polyhedra around the sodium cations are considerably distorted. The two types of cations are bridged into polymeric chains extending parallel to [010]. This arrangement is stabilized by intrachain O—H⋯O hydrogen bonds between methanol ligands as donor and carboxyl­ate O atoms as acceptor groups. The hydro­phobic 6-meth­oxy­naphthyl moieties flank the hydro­philic sodium oxygen chains into ribbons parallel to [010]. There are no noticeable inter­molecular inter­actions between these ribbons. One of the 6-meth­oxy­naphthyl moieties is disordered over two sets of sites in a 0.723 (3):0.277 (3) ratio.