Correcting palindromes in long reads after whole-genome amplification

BACKGROUND: Next-generation sequencing requires sufficient DNA to be available. If limited, whole-genome amplification is applied to generate additional amounts of DNA. Such amplification often results in many chimeric DNA fragments, in particular artificial palindromic sequences, which limit the us...

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Detalles Bibliográficos
Autores principales: Warris, Sven, Schijlen, Elio, van de Geest, Henri, Vegesna, Rahulsimham, Hesselink, Thamara, te Lintel Hekkert, Bas, Sanchez Perez, Gabino, Medvedev, Paul, Makova, Kateryna D., de Ridder, Dick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218980/
https://www.ncbi.nlm.nih.gov/pubmed/30400848
http://dx.doi.org/10.1186/s12864-018-5164-1

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