DELTA(2) guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

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BACKGROUND: A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for the primary outcome and then calculate the required sample size. The sample size is chosen to ensur...

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Detalles Bibliográficos
Autores principales: Cook, Jonathan A., Julious, Steven A., Sones, William, Hampson, Lisa V., Hewitt, Catherine, Berlin, Jesse A., Ashby, Deborah, Emsley, Richard, Fergusson, Dean A., Walters, Stephen J., Wilson, Edward C. F., Maclennan, Graeme, Stallard, Nigel, Rothwell, Joanne C., Bland, Martin, Brown, Louise, Ramsay, Craig R., Cook, Andrew, Armstrong, David, Altman, Doug, Vale, Luke D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218987/
https://www.ncbi.nlm.nih.gov/pubmed/30400926
http://dx.doi.org/10.1186/s13063-018-2884-0
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